Cargando…

X-ray structures and mechanism of the human serotonin transporter

The serotonin transporter (SERT) terminates serotonergic signaling through the sodium and chloride dependent reuptake of neurotransmitter into presynaptic neurons. SERT is a target for antidepressant and psychostimulant drugs, which block reuptake and prolong neurotransmitter signaling. Here we repo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coleman, Jonathan A., Green, Evan M., Gouaux, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898786/ https://www.ncbi.nlm.nih.gov/pubmed/27049939 http://dx.doi.org/10.1038/nature17629

Ejemplares similares

Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation
por: Green, Evan M., et al.
Publicado: (2015)

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
por: Coleman, Jonathan A., et al.
Publicado: (2016)

Chemical and structural investigation of the paroxetine-human serotonin transporter complex
por: Coleman, Jonathan A, et al.
Publicado: (2020)

Illumination of serotonin transporter mechanism and role of the allosteric site
por: Yang, Dongxue, et al.
Publicado: (2021)

Structures and membrane interactions of native serotonin transporter in complexes with psychostimulants
por: Yang, Dongxue, et al.
Publicado: (2023)

Extracellular loops of the serotonin transporter act as a selectivity filter for drug binding
por: Esendir, Eray, et al.
Publicado: (2021)

The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter
por: Plenge, Per, et al.
Publicado: (2021)

Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography
por: Yoder, Nate, et al.
Publicado: (2018)

Correction: Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography
por: Yoder, Nate, et al.
Publicado: (2018)

The molecular logic of sodium-coupled neurotransmitter transporters
por: Gouaux, Eric
Publicado: (2008)

Mechanism of Paroxetine (Paxil) Inhibition of the Serotonin Transporter
por: Davis, Bruce A., et al.
Publicado: (2016)

Serotonin and serotonin transporter levels in autistic children
por: Abdulamir, Haidar A., et al.
Publicado: (2018)

A structural model of the human serotonin transporter in an outward-occluded state
por: Hellsberg, Eva, et al.
Publicado: (2019)

Structural basis for action by diverse antidepressants on biogenic amine transporters
por: Wang, Hui, et al.
Publicado: (2013)

Crystal structure of the ATP-gated P2X4 ion channel in the closed state
por: Kawate, Toshimitsu, et al.
Publicado: (2009)

How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure
por: Kobiella, A, et al.
Publicado: (2011)

A mechanism of uncompetitive inhibition of the serotonin transporter
por: Bhat, Shreyas, et al.
Publicado: (2023)

X-ray structures of the high-affinity copper transporter Ctr1
por: Ren, Feifei, et al.
Publicado: (2019)

Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation
por: Navratna, Vikas, et al.
Publicado: (2018)

Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain
por: Gradisch, Ralph, et al.
Publicado: (2022)

The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
por: Plenge, Per, et al.
Publicado: (2020)

Pore architecture and ion sites in acid sensing ion channels and P2X receptors
por: Gonzales, Eric B., et al.
Publicado: (2009)

The expression of platelet serotonin transporter (SERT) in human obesity
por: Giannaccini, Gino, et al.
Publicado: (2013)

Beam Transport In The Crystal X-ray Accelerator
por: Tajima, T, et al.
Publicado: (1990)

Serotonin Transporter Binding in the Diencephalon Is Reduced in Insulin-Resistant Obese Humans
por: Versteeg, Ruth I., et al.
Publicado: (2017)

The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network
por: Ahmed, Billow A., et al.
Publicado: (2009)

Functional and Structural Neural Network Characterization of Serotonin Transporter Knockout Rats
por: van der Marel, Kajo, et al.
Publicado: (2013)

The serotonin transporter sustains human brown adipose tissue thermogenesis
por: Suchacki, Karla J., et al.
Publicado: (2023)

Serotonin Transporter Binding in Major Depressive Disorder: Impact of Serotonin System Anatomy
por: Bartlett, Elizabeth A, et al.
Publicado: (2022)

Structure and Regulatory Interactions of the Cytoplasmic Terminal Domains of Serotonin Transporter
por: Fenollar-Ferrer, Cristina, et al.
Publicado: (2014)

Evidence for a Role of Transporter-Mediated Currents in the Depletion of Brain Serotonin Induced by Serotonin Transporter Substrates
por: Baumann, Michael H, et al.
Publicado: (2014)

Evaluation of serotonin and serotonin transporter levels among Obstructive Sleep Apnea patients
por: Gabryelska, A., et al.
Publicado: (2023)

Dimer Interface of the Human Serotonin Transporter and Effect of the Membrane Composition
por: Periole, Xavier, et al.
Publicado: (2018)

Mouse model of the human serotonin transporter-linked polymorphic region
por: Piszczek, Lukasz, et al.
Publicado: (2019)

The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter
por: Kern, Carina, et al.
Publicado: (2017)

Imaging of serotonin transporters with [(123)I]FP-CIT SPECT in the human hypothalamus
por: Borgers, Anke J, et al.
Publicado: (2013)

Influence of X-rays and gamma-rays on the mechanical performance of human bone factoring out intraindividual bone structure and composition indices
por: Schmidt, Felix N., et al.
Publicado: (2021)

Structural dissection of human metapneumovirus phosphoprotein using small angle x-ray scattering
por: Renner, Max, et al.
Publicado: (2017)

Structure determination by X-ray crystallography
por: Ladd, M F C, et al.
Publicado: (1977)

Structure determination by X-ray crystallography
por: Ladd, M F C, et al.
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_lkid7gn5c3jtt1org25s569qtd