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Health technology assessment of image-guided radiotherapy (IGRT): A systematic review of current evidence

Background: Image-guided radiotherapy used multiple imaging during the radiation therapy course to improve the precision and accuracy of health care provider's treatment. Objectives: This study aims to assess the safety, effectiveness and economic aspects of image-guided radiation therapy for d...

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Autores principales: Arabloo, Jalal, Hamouzadeh, Pejman, Mousavinezhad, Seyedeh Maryam, Mobinizadeh, Mohammadreza, Olyaeemanesh, Alireza, Pooyandjoo, Morvarid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iran University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898870/
https://www.ncbi.nlm.nih.gov/pubmed/27390688
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author Arabloo, Jalal
Hamouzadeh, Pejman
Mousavinezhad, Seyedeh Maryam
Mobinizadeh, Mohammadreza
Olyaeemanesh, Alireza
Pooyandjoo, Morvarid
author_facet Arabloo, Jalal
Hamouzadeh, Pejman
Mousavinezhad, Seyedeh Maryam
Mobinizadeh, Mohammadreza
Olyaeemanesh, Alireza
Pooyandjoo, Morvarid
author_sort Arabloo, Jalal
collection PubMed
description Background: Image-guided radiotherapy used multiple imaging during the radiation therapy course to improve the precision and accuracy of health care provider's treatment. Objectives: This study aims to assess the safety, effectiveness and economic aspects of image-guided radiation therapy for decision-making about this technology in Iran. Methods: In this study, the most important medical databases such as PubMed and Cochrane Library were searched until November 2014. The systematic reviews, health technology assessment reports and economic evaluation studies were included. The results of included studies were analyzed via the thematic synthesis. Results: Seven articles were included in the study. The results showed that image-guided radiation therapy, regardless of the imaging technique used in it, is associated with no major toxicity and has the potential to reduce the symptoms of poisoning. Using image-guided radiation therapy for prostate cancer resulted in substantial improvement in the quality of the received dose and optimal therapeutic dose of radiation to the targeted tumor while the radiation dose to the surrounding healthy tissues was minimal. Additionally, image-guided radiation therapy facilitated the diagnosis and management of exception deviations, including immediate changes and gross errors, weight loss, significant limbs deformity, systematic changes in the internal organs and changes in respiratory movements. Usage of image-guided radiation therapy for prostate cancer was associated with increased costs. Conclusion: Current available evidence suggests that the image-guided radiation therapy can reduce the amount of radiation to healthy tissue around the tumor and the toxicity associated with it. This can enhance the safe dose of radiation to the tumor and increase the likelihood of destruction of tumor. The current level of evidence required conducting further studies on the costs and effectiveness of this technology compared with conventional technology.
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spelling pubmed-48988702016-07-07 Health technology assessment of image-guided radiotherapy (IGRT): A systematic review of current evidence Arabloo, Jalal Hamouzadeh, Pejman Mousavinezhad, Seyedeh Maryam Mobinizadeh, Mohammadreza Olyaeemanesh, Alireza Pooyandjoo, Morvarid Med J Islam Repub Iran Original Article Background: Image-guided radiotherapy used multiple imaging during the radiation therapy course to improve the precision and accuracy of health care provider's treatment. Objectives: This study aims to assess the safety, effectiveness and economic aspects of image-guided radiation therapy for decision-making about this technology in Iran. Methods: In this study, the most important medical databases such as PubMed and Cochrane Library were searched until November 2014. The systematic reviews, health technology assessment reports and economic evaluation studies were included. The results of included studies were analyzed via the thematic synthesis. Results: Seven articles were included in the study. The results showed that image-guided radiation therapy, regardless of the imaging technique used in it, is associated with no major toxicity and has the potential to reduce the symptoms of poisoning. Using image-guided radiation therapy for prostate cancer resulted in substantial improvement in the quality of the received dose and optimal therapeutic dose of radiation to the targeted tumor while the radiation dose to the surrounding healthy tissues was minimal. Additionally, image-guided radiation therapy facilitated the diagnosis and management of exception deviations, including immediate changes and gross errors, weight loss, significant limbs deformity, systematic changes in the internal organs and changes in respiratory movements. Usage of image-guided radiation therapy for prostate cancer was associated with increased costs. Conclusion: Current available evidence suggests that the image-guided radiation therapy can reduce the amount of radiation to healthy tissue around the tumor and the toxicity associated with it. This can enhance the safe dose of radiation to the tumor and increase the likelihood of destruction of tumor. The current level of evidence required conducting further studies on the costs and effectiveness of this technology compared with conventional technology. Iran University of Medical Sciences 2016-01-18 /pmc/articles/PMC4898870/ /pubmed/27390688 Text en © 2016 Iran University of Medical Sciences http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial 3.0 License (CC BY-NC 3.0), which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Arabloo, Jalal
Hamouzadeh, Pejman
Mousavinezhad, Seyedeh Maryam
Mobinizadeh, Mohammadreza
Olyaeemanesh, Alireza
Pooyandjoo, Morvarid
Health technology assessment of image-guided radiotherapy (IGRT): A systematic review of current evidence
title Health technology assessment of image-guided radiotherapy (IGRT): A systematic review of current evidence
title_full Health technology assessment of image-guided radiotherapy (IGRT): A systematic review of current evidence
title_fullStr Health technology assessment of image-guided radiotherapy (IGRT): A systematic review of current evidence
title_full_unstemmed Health technology assessment of image-guided radiotherapy (IGRT): A systematic review of current evidence
title_short Health technology assessment of image-guided radiotherapy (IGRT): A systematic review of current evidence
title_sort health technology assessment of image-guided radiotherapy (igrt): a systematic review of current evidence
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898870/
https://www.ncbi.nlm.nih.gov/pubmed/27390688
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