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Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients
The G2385R variant of the leucine-rich repeat kinase 2 (LRRK2) is strongly associated with Parkinson’s disease (PD) in Asian populations. However, it is still unclear whether the clinical phenotype of PD patients with the G2385R variant can be distinguished from that of patients with idiopathic PD....
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JKL International LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898919/ https://www.ncbi.nlm.nih.gov/pubmed/27330837 http://dx.doi.org/10.14336/AD.2015.1026 |
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author | Sun, Qian Wang, Tian Jiang, Tian-Fang Huang, Pei Li, Dun-Hui Wang, Ying Xiao, Qin Liu, Jun Chen, Sheng-Di |
author_facet | Sun, Qian Wang, Tian Jiang, Tian-Fang Huang, Pei Li, Dun-Hui Wang, Ying Xiao, Qin Liu, Jun Chen, Sheng-Di |
author_sort | Sun, Qian |
collection | PubMed |
description | The G2385R variant of the leucine-rich repeat kinase 2 (LRRK2) is strongly associated with Parkinson’s disease (PD) in Asian populations. However, it is still unclear whether the clinical phenotype of PD patients with the G2385R variant can be distinguished from that of patients with idiopathic PD. In this study, we investigated motor and non-motor symptoms of LRRK2 G2385R variant carriers in a Chinese population. We genotyped 1031 Chinese PD patients for the G2385R variant of the LRRK2 gene, and examined the demographic and clinical characteristics of LRRK2 G2385R variant carrier and non-carrier PD patients. LRRK2 G2385R variant carriers were more likely to present the postural instability and gait difficulty dominant (PIGD) phenotype. This variant was also significantly associated with motor fluctuations and the levodopa equivalent dose (LED). G2385R variant carriers had higher REM sleep behavior disorder (RBD) screening questionnaire (RBDSQ) score and more RBD symptoms compared with non-carriers. We concluded that the G2385R variant could be a risk factor for the PIGD phenotype, motor fluctuations, LED values and RBD symptoms. |
format | Online Article Text |
id | pubmed-4898919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | JKL International LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-48989192016-06-21 Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients Sun, Qian Wang, Tian Jiang, Tian-Fang Huang, Pei Li, Dun-Hui Wang, Ying Xiao, Qin Liu, Jun Chen, Sheng-Di Aging Dis Original Article The G2385R variant of the leucine-rich repeat kinase 2 (LRRK2) is strongly associated with Parkinson’s disease (PD) in Asian populations. However, it is still unclear whether the clinical phenotype of PD patients with the G2385R variant can be distinguished from that of patients with idiopathic PD. In this study, we investigated motor and non-motor symptoms of LRRK2 G2385R variant carriers in a Chinese population. We genotyped 1031 Chinese PD patients for the G2385R variant of the LRRK2 gene, and examined the demographic and clinical characteristics of LRRK2 G2385R variant carrier and non-carrier PD patients. LRRK2 G2385R variant carriers were more likely to present the postural instability and gait difficulty dominant (PIGD) phenotype. This variant was also significantly associated with motor fluctuations and the levodopa equivalent dose (LED). G2385R variant carriers had higher REM sleep behavior disorder (RBD) screening questionnaire (RBDSQ) score and more RBD symptoms compared with non-carriers. We concluded that the G2385R variant could be a risk factor for the PIGD phenotype, motor fluctuations, LED values and RBD symptoms. JKL International LLC 2016-05-27 /pmc/articles/PMC4898919/ /pubmed/27330837 http://dx.doi.org/10.14336/AD.2015.1026 Text en Copyright: © 2016 Sun, Q, et al. http://creativecommons.org/licenses/by/2.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | Original Article Sun, Qian Wang, Tian Jiang, Tian-Fang Huang, Pei Li, Dun-Hui Wang, Ying Xiao, Qin Liu, Jun Chen, Sheng-Di Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients |
title | Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients |
title_full | Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients |
title_fullStr | Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients |
title_full_unstemmed | Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients |
title_short | Effect of a Leucine-rich Repeat Kinase 2 Variant on Motor and Non-motor Symptoms in Chinese Parkinson’s Disease Patients |
title_sort | effect of a leucine-rich repeat kinase 2 variant on motor and non-motor symptoms in chinese parkinson’s disease patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898919/ https://www.ncbi.nlm.nih.gov/pubmed/27330837 http://dx.doi.org/10.14336/AD.2015.1026 |
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