MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis

Osteoarthritis (OA) is the most prevalent degenerative joint disease with multifactorial etiology caused by risk factors such as ageing, obesity and trauma. Previously, it was reported that the inhibition of microRNA-34a (miR-34a) may reduce rat chondrocyte apoptosis induced by IL-1β, whereas the mo...

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Detalles Bibliográficos
Autores principales: YAN, SHIJU, WANG, MENG, ZHAO, JIAN, ZHANG, HONGTAO, ZHOU, CHENGPEI, JIN, LEI, ZHANG, YINGLONG, QIU, XIUCHUN, MA, BAOAN, FAN, QINGYU
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899008/
https://www.ncbi.nlm.nih.gov/pubmed/27247228
http://dx.doi.org/10.3892/ijmm.2016.2618

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899008/
https://www.ncbi.nlm.nih.gov/pubmed/27247228
http://dx.doi.org/10.3892/ijmm.2016.2618

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