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Identification of novel potent human testis-specific and bromodomain-containing protein (BRDT) inhibitors using crystal structure-based virtual screening

Human testis-specific and bromodomain-containing protein (hBRDT) is essential for chromatin remodeling during spermatogenesis and is therefore an attractive target for the discovery of male contraceptive drugs. In this study, pharmacophore modeling was carried out based on the crystal structure of h...

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Detalles Bibliográficos
Autores principales:	GAO, NANA, REN, JIXIA, HOU, LI, ZHOU, YUE, XIN, LING, WANG, JIEDONG, YU, HEMING, XIE, YONG, WANG, HUIPING
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899012/ https://www.ncbi.nlm.nih.gov/pubmed/27220398 http://dx.doi.org/10.3892/ijmm.2016.2602

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