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miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer

MicroRNAs play an important role in the regulation of cancer migration, invasion and metastasis. Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for metastasis and recurrence in these individuals remains largely u...

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Autores principales: YAN, MEISI, LI, XIAOBO, TONG, DANDAN, HAN, CHANGSONG, ZHAO, RAN, HE, YAN, JIN, XIAOMING
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899014/
https://www.ncbi.nlm.nih.gov/pubmed/27108696
http://dx.doi.org/10.3892/or.2016.4767
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author YAN, MEISI
LI, XIAOBO
TONG, DANDAN
HAN, CHANGSONG
ZHAO, RAN
HE, YAN
JIN, XIAOMING
author_facet YAN, MEISI
LI, XIAOBO
TONG, DANDAN
HAN, CHANGSONG
ZHAO, RAN
HE, YAN
JIN, XIAOMING
author_sort YAN, MEISI
collection PubMed
description MicroRNAs play an important role in the regulation of cancer migration, invasion and metastasis. Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for metastasis and recurrence in these individuals remains largely unknown. Herein, we demonstrate that miR-136 is an anti-invasive microRNA in TNBC and suppresses mesenchymal invasion and metastasis. Our results demonstrated that miR-136 was downregulated in TNBC and negative correlated with the WHO grades. However, RASAL2 was identified as a functional target of miR-136, and was overexpressed in TNBC and correlates with pathological grades. Moreover, overexpression of RASAL2 in a breast cancer cell line rescued miR-136-mediated cell migration and invasion. In conclusion, these results indicate that the miR-136/RASAL2/MET axis act as a suppressor of TNBC metastasis.
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spelling pubmed-48990142016-06-16 miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer YAN, MEISI LI, XIAOBO TONG, DANDAN HAN, CHANGSONG ZHAO, RAN HE, YAN JIN, XIAOMING Oncol Rep Articles MicroRNAs play an important role in the regulation of cancer migration, invasion and metastasis. Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for metastasis and recurrence in these individuals remains largely unknown. Herein, we demonstrate that miR-136 is an anti-invasive microRNA in TNBC and suppresses mesenchymal invasion and metastasis. Our results demonstrated that miR-136 was downregulated in TNBC and negative correlated with the WHO grades. However, RASAL2 was identified as a functional target of miR-136, and was overexpressed in TNBC and correlates with pathological grades. Moreover, overexpression of RASAL2 in a breast cancer cell line rescued miR-136-mediated cell migration and invasion. In conclusion, these results indicate that the miR-136/RASAL2/MET axis act as a suppressor of TNBC metastasis. D.A. Spandidos 2016-07 2016-04-25 /pmc/articles/PMC4899014/ /pubmed/27108696 http://dx.doi.org/10.3892/or.2016.4767 Text en Copyright: © Yan et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
YAN, MEISI
LI, XIAOBO
TONG, DANDAN
HAN, CHANGSONG
ZHAO, RAN
HE, YAN
JIN, XIAOMING
miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer
title miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer
title_full miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer
title_fullStr miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer
title_full_unstemmed miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer
title_short miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer
title_sort mir-136 suppresses tumor invasion and metastasis by targeting rasal2 in triple-negative breast cancer
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899014/
https://www.ncbi.nlm.nih.gov/pubmed/27108696
http://dx.doi.org/10.3892/or.2016.4767
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