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miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer
MicroRNAs play an important role in the regulation of cancer migration, invasion and metastasis. Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for metastasis and recurrence in these individuals remains largely u...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899014/ https://www.ncbi.nlm.nih.gov/pubmed/27108696 http://dx.doi.org/10.3892/or.2016.4767 |
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author | YAN, MEISI LI, XIAOBO TONG, DANDAN HAN, CHANGSONG ZHAO, RAN HE, YAN JIN, XIAOMING |
author_facet | YAN, MEISI LI, XIAOBO TONG, DANDAN HAN, CHANGSONG ZHAO, RAN HE, YAN JIN, XIAOMING |
author_sort | YAN, MEISI |
collection | PubMed |
description | MicroRNAs play an important role in the regulation of cancer migration, invasion and metastasis. Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for metastasis and recurrence in these individuals remains largely unknown. Herein, we demonstrate that miR-136 is an anti-invasive microRNA in TNBC and suppresses mesenchymal invasion and metastasis. Our results demonstrated that miR-136 was downregulated in TNBC and negative correlated with the WHO grades. However, RASAL2 was identified as a functional target of miR-136, and was overexpressed in TNBC and correlates with pathological grades. Moreover, overexpression of RASAL2 in a breast cancer cell line rescued miR-136-mediated cell migration and invasion. In conclusion, these results indicate that the miR-136/RASAL2/MET axis act as a suppressor of TNBC metastasis. |
format | Online Article Text |
id | pubmed-4899014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-48990142016-06-16 miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer YAN, MEISI LI, XIAOBO TONG, DANDAN HAN, CHANGSONG ZHAO, RAN HE, YAN JIN, XIAOMING Oncol Rep Articles MicroRNAs play an important role in the regulation of cancer migration, invasion and metastasis. Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for metastasis and recurrence in these individuals remains largely unknown. Herein, we demonstrate that miR-136 is an anti-invasive microRNA in TNBC and suppresses mesenchymal invasion and metastasis. Our results demonstrated that miR-136 was downregulated in TNBC and negative correlated with the WHO grades. However, RASAL2 was identified as a functional target of miR-136, and was overexpressed in TNBC and correlates with pathological grades. Moreover, overexpression of RASAL2 in a breast cancer cell line rescued miR-136-mediated cell migration and invasion. In conclusion, these results indicate that the miR-136/RASAL2/MET axis act as a suppressor of TNBC metastasis. D.A. Spandidos 2016-07 2016-04-25 /pmc/articles/PMC4899014/ /pubmed/27108696 http://dx.doi.org/10.3892/or.2016.4767 Text en Copyright: © Yan et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles YAN, MEISI LI, XIAOBO TONG, DANDAN HAN, CHANGSONG ZHAO, RAN HE, YAN JIN, XIAOMING miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer |
title | miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer |
title_full | miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer |
title_fullStr | miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer |
title_full_unstemmed | miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer |
title_short | miR-136 suppresses tumor invasion and metastasis by targeting RASAL2 in triple-negative breast cancer |
title_sort | mir-136 suppresses tumor invasion and metastasis by targeting rasal2 in triple-negative breast cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899014/ https://www.ncbi.nlm.nih.gov/pubmed/27108696 http://dx.doi.org/10.3892/or.2016.4767 |
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