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Cinobufagin induces autophagy-mediated cell death in human osteosarcoma U2OS cells through the ROS/JNK/p38 signaling pathway

The main objective of this study was to explore whether autophagy could be triggered by cinobufagin, and to clarify the role of autophagy in the antitumor effects of cinobufagin on U2OS cells and the underlying mechanisms. U2OS cells were exposed to 15, 30, 60 and 120 mg/l cinobufagin for 0, 12, 24...

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Detalles Bibliográficos
Autores principales:	MA, KUN, ZHANG, CHUAN, HUANG, MAN-YU, LI, WU-YIN, HU, GUO-QIANG
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899018/ https://www.ncbi.nlm.nih.gov/pubmed/27176794 http://dx.doi.org/10.3892/or.2016.4782

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