Activation of the ESC pluripotency factor OCT4 in smooth muscle cells is atheroprotective

There are controversial claims that the embryonic stem cell (ESC) pluripotency factor OCT4 is activated in somatic cells, but there is no evidence it plays a functional role in these cells. Herein we demonstrate that smooth muscle cell (SMC)-specific conditional knockout of Oct4 within Apoe(−/−) mic...

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Detalles Bibliográficos
Autores principales: Cherepanova, Olga A., Gomez, Delphine, Shankman, Laura S., Swiatlowska, Pamela, Williams, Jason, Sarmento, Olga F., Alencar, Gabriel F., Hess, Daniel L., Bevard, Melissa H., Greene, Elizabeth S., Murgai, Meera, Turner, Stephen D., Geng, Yong-Jian, Bekiranov, Stefan, Connelly, Jessica J., Tomilin, Alexey, Owens, Gary K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899256/
https://www.ncbi.nlm.nih.gov/pubmed/27183216
http://dx.doi.org/10.1038/nm.4109

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