A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma

We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow...

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Autores principales: Costantini, Danny L., Vali, Reza, McQuattie, Susan, Chan, Jeffrey, Punnett, Angela, Weitzman, Shiela, Shammas, Amer, Charron, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899586/
https://www.ncbi.nlm.nih.gov/pubmed/27313888
http://dx.doi.org/10.1155/2016/6045894
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author Costantini, Danny L.
Vali, Reza
McQuattie, Susan
Chan, Jeffrey
Punnett, Angela
Weitzman, Shiela
Shammas, Amer
Charron, Martin
author_facet Costantini, Danny L.
Vali, Reza
McQuattie, Susan
Chan, Jeffrey
Punnett, Angela
Weitzman, Shiela
Shammas, Amer
Charron, Martin
author_sort Costantini, Danny L.
collection PubMed
description We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0.4, respectively. Nonspecific uptake in reactive lymph nodes and thymus was observed. Future studies to assess the clinical utility of 18F-FLT PET/CT in pediatric lymphoma are planned.
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spelling pubmed-48995862016-06-16 A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma Costantini, Danny L. Vali, Reza McQuattie, Susan Chan, Jeffrey Punnett, Angela Weitzman, Shiela Shammas, Amer Charron, Martin Int J Mol Imaging Research Article We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0.4, respectively. Nonspecific uptake in reactive lymph nodes and thymus was observed. Future studies to assess the clinical utility of 18F-FLT PET/CT in pediatric lymphoma are planned. Hindawi Publishing Corporation 2016 2016-05-26 /pmc/articles/PMC4899586/ /pubmed/27313888 http://dx.doi.org/10.1155/2016/6045894 Text en Copyright © 2016 Danny L. Costantini et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Costantini, Danny L.
Vali, Reza
McQuattie, Susan
Chan, Jeffrey
Punnett, Angela
Weitzman, Shiela
Shammas, Amer
Charron, Martin
A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma
title A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma
title_full A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma
title_fullStr A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma
title_full_unstemmed A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma
title_short A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma
title_sort pilot study of 18f-flt pet/ct in pediatric lymphoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899586/
https://www.ncbi.nlm.nih.gov/pubmed/27313888
http://dx.doi.org/10.1155/2016/6045894
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