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Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains

Herpesviridae family is one of the significant viral families which comprises major pathogens of a wide range of hosts. This family includes at least eight species of viruses which are known to infect humans. This family has evolved 180–220 million years ago and the present study highlights that it...

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Autores principales: Sharma, Vikas, Mobeen, Fauzul, Prakash, Tulika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899598/
https://www.ncbi.nlm.nih.gov/pubmed/27314006
http://dx.doi.org/10.1155/2016/9543274
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author Sharma, Vikas
Mobeen, Fauzul
Prakash, Tulika
author_facet Sharma, Vikas
Mobeen, Fauzul
Prakash, Tulika
author_sort Sharma, Vikas
collection PubMed
description Herpesviridae family is one of the significant viral families which comprises major pathogens of a wide range of hosts. This family includes at least eight species of viruses which are known to infect humans. This family has evolved 180–220 million years ago and the present study highlights that it is still evolving and more genes can be added to the repertoire of this family. In addition, its core-genome includes important viral proteins including glycoprotein B and helicase. Most of the infections caused by human herpesviruses have no definitive cure; thus, search for new therapeutic strategies is necessary. The present study finds core-genome of human herpesviruses that differs from that of Herpesviridae family and nonhuman herpes strains of this family and might be a putative target for vaccine development. The phylogenetic reconstruction based upon the protein sequences of core gene set of Herpesviridae family reveals the sharp splits of its different subfamilies and supports the hypothesis of coevolution of viruses with their hosts. In addition, data mining for cis-elements in the genomes of human herpesviruses results in the prediction of numerous regulatory elements which can be used for regulating the expression of viral based vectors implicated in gene therapies.
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spelling pubmed-48995982016-06-16 Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains Sharma, Vikas Mobeen, Fauzul Prakash, Tulika Int J Genomics Research Article Herpesviridae family is one of the significant viral families which comprises major pathogens of a wide range of hosts. This family includes at least eight species of viruses which are known to infect humans. This family has evolved 180–220 million years ago and the present study highlights that it is still evolving and more genes can be added to the repertoire of this family. In addition, its core-genome includes important viral proteins including glycoprotein B and helicase. Most of the infections caused by human herpesviruses have no definitive cure; thus, search for new therapeutic strategies is necessary. The present study finds core-genome of human herpesviruses that differs from that of Herpesviridae family and nonhuman herpes strains of this family and might be a putative target for vaccine development. The phylogenetic reconstruction based upon the protein sequences of core gene set of Herpesviridae family reveals the sharp splits of its different subfamilies and supports the hypothesis of coevolution of viruses with their hosts. In addition, data mining for cis-elements in the genomes of human herpesviruses results in the prediction of numerous regulatory elements which can be used for regulating the expression of viral based vectors implicated in gene therapies. Hindawi Publishing Corporation 2016 2016-05-26 /pmc/articles/PMC4899598/ /pubmed/27314006 http://dx.doi.org/10.1155/2016/9543274 Text en Copyright © 2016 Vikas Sharma et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sharma, Vikas
Mobeen, Fauzul
Prakash, Tulika
Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains
title Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains
title_full Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains
title_fullStr Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains
title_full_unstemmed Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains
title_short Comparative Genomics of Herpesviridae Family to Look for Potential Signatures of Human Infecting Strains
title_sort comparative genomics of herpesviridae family to look for potential signatures of human infecting strains
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899598/
https://www.ncbi.nlm.nih.gov/pubmed/27314006
http://dx.doi.org/10.1155/2016/9543274
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