Simultaneous optical and electrical in vivo analysis of the enteric nervous system

The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its...

Descripción completa

Detalles Bibliográficos
Autores principales: Rakhilin, Nikolai, Barth, Bradley, Choi, Jiahn, Muñoz, Nini L., Kulkarni, Subhash, Jones, Jason S., Small, David M., Cheng, Yu-Ting, Cao, Yingqiu, LaVinka, Colleen, Kan, Edwin, Dong, Xinzhong, Spencer, Michael, Pasricha, Pankaj, Nishimura, Nozomi, Shen, Xiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899629/
https://www.ncbi.nlm.nih.gov/pubmed/27270085
http://dx.doi.org/10.1038/ncomms11800
_version_ 1782436497253728256
author Rakhilin, Nikolai
Barth, Bradley
Choi, Jiahn
Muñoz, Nini L.
Kulkarni, Subhash
Jones, Jason S.
Small, David M.
Cheng, Yu-Ting
Cao, Yingqiu
LaVinka, Colleen
Kan, Edwin
Dong, Xinzhong
Spencer, Michael
Pasricha, Pankaj
Nishimura, Nozomi
Shen, Xiling
author_facet Rakhilin, Nikolai
Barth, Bradley
Choi, Jiahn
Muñoz, Nini L.
Kulkarni, Subhash
Jones, Jason S.
Small, David M.
Cheng, Yu-Ting
Cao, Yingqiu
LaVinka, Colleen
Kan, Edwin
Dong, Xinzhong
Spencer, Michael
Pasricha, Pankaj
Nishimura, Nozomi
Shen, Xiling
author_sort Rakhilin, Nikolai
collection PubMed
description The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its activity in live animals. Here, we integrate a transparent graphene sensor with a customized abdominal window for simultaneous optical and electrical recording of the ENS in vivo. The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time.
format Online
Article
Text
id pubmed-4899629
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-48996292016-06-22 Simultaneous optical and electrical in vivo analysis of the enteric nervous system Rakhilin, Nikolai Barth, Bradley Choi, Jiahn Muñoz, Nini L. Kulkarni, Subhash Jones, Jason S. Small, David M. Cheng, Yu-Ting Cao, Yingqiu LaVinka, Colleen Kan, Edwin Dong, Xinzhong Spencer, Michael Pasricha, Pankaj Nishimura, Nozomi Shen, Xiling Nat Commun Article The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its activity in live animals. Here, we integrate a transparent graphene sensor with a customized abdominal window for simultaneous optical and electrical recording of the ENS in vivo. The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time. Nature Publishing Group 2016-06-07 /pmc/articles/PMC4899629/ /pubmed/27270085 http://dx.doi.org/10.1038/ncomms11800 Text en Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Rakhilin, Nikolai
Barth, Bradley
Choi, Jiahn
Muñoz, Nini L.
Kulkarni, Subhash
Jones, Jason S.
Small, David M.
Cheng, Yu-Ting
Cao, Yingqiu
LaVinka, Colleen
Kan, Edwin
Dong, Xinzhong
Spencer, Michael
Pasricha, Pankaj
Nishimura, Nozomi
Shen, Xiling
Simultaneous optical and electrical in vivo analysis of the enteric nervous system
title Simultaneous optical and electrical in vivo analysis of the enteric nervous system
title_full Simultaneous optical and electrical in vivo analysis of the enteric nervous system
title_fullStr Simultaneous optical and electrical in vivo analysis of the enteric nervous system
title_full_unstemmed Simultaneous optical and electrical in vivo analysis of the enteric nervous system
title_short Simultaneous optical and electrical in vivo analysis of the enteric nervous system
title_sort simultaneous optical and electrical in vivo analysis of the enteric nervous system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899629/
https://www.ncbi.nlm.nih.gov/pubmed/27270085
http://dx.doi.org/10.1038/ncomms11800
work_keys_str_mv AT rakhilinnikolai simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT barthbradley simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT choijiahn simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT munozninil simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT kulkarnisubhash simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT jonesjasons simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT smalldavidm simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT chengyuting simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT caoyingqiu simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT lavinkacolleen simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT kanedwin simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT dongxinzhong simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT spencermichael simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT pasrichapankaj simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT nishimuranozomi simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem
AT shenxiling simultaneousopticalandelectricalinvivoanalysisoftheentericnervoussystem

Ejemplares similares