Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor

Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dens...

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Autores principales: Shido, Kosuke, Fujimura, Taku, Kakizaki, Aya, Furudate, Sadanori, Asano, Masayuki, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2016
Materias:
Published online: February, 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899637/
https://www.ncbi.nlm.nih.gov/pubmed/27293390
http://dx.doi.org/10.1159/000444045
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author Shido, Kosuke
Fujimura, Taku
Kakizaki, Aya
Furudate, Sadanori
Asano, Masayuki
Aiba, Setsuya
author_facet Shido, Kosuke
Fujimura, Taku
Kakizaki, Aya
Furudate, Sadanori
Asano, Masayuki
Aiba, Setsuya
author_sort Shido, Kosuke
collection PubMed
description Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206– tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT.
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spelling pubmed-48996372016-06-10 Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor Shido, Kosuke Fujimura, Taku Kakizaki, Aya Furudate, Sadanori Asano, Masayuki Aiba, Setsuya Case Rep Dermatol Published online: February, 2016 Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206– tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT. S. Karger AG 2016-02-05 /pmc/articles/PMC4899637/ /pubmed/27293390 http://dx.doi.org/10.1159/000444045 Text en Copyright © 2016 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Published online: February, 2016
Shido, Kosuke
Fujimura, Taku
Kakizaki, Aya
Furudate, Sadanori
Asano, Masayuki
Aiba, Setsuya
Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_full Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_fullStr Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_full_unstemmed Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_short Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_sort plexiform fibrohistiocytic tumor on the ear: case report and immunohistochemical investigation of stromal factor
topic Published online: February, 2016
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899637/
https://www.ncbi.nlm.nih.gov/pubmed/27293390
http://dx.doi.org/10.1159/000444045
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