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Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum

The malaria parasite Plasmodium falciparum relies on efficient protein translation. An essential component of translation is the tryptophanyl-tRNA synthetase (TrpRS) that charges tRNA(trp). Here we characterise two isoforms of TrpRS in Plasmodium; one eukaryotic type localises to the cytosol and a b...

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Detalles Bibliográficos
Autores principales:	Pasaje, Charisse Flerida A., Cheung, Vanessa, Kennedy, Kit, Lim, Erin E., Baell, Jonathan B., Griffin, Michael D. W., Ralph, Stuart A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899734/ https://www.ncbi.nlm.nih.gov/pubmed/27277538 http://dx.doi.org/10.1038/srep27531

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