Cargando…

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

Pancreatic cancer is the leading cause of cancer death worldwide with a poor survival rate. The objective of this study was to determine the mechanism of action of a novel antimitotic and Stat3 inhibitor, LTP-1, on human pancreatic cancer in vitro and in vivo. We found that LTP-1 inhibited pancreati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Han-Li, Chao, Min-Wu, Chen, Chung-Chun, Cheng, Chun-Chun, Chen, Mei-Chuan, Lin, Chao-Feng, Liou, Jing-Ping, Teng, Che-Ming, Pan, Shiow-Lin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899784/ https://www.ncbi.nlm.nih.gov/pubmed/27278358 http://dx.doi.org/10.1038/srep27794

Ejemplares similares

Photopharmacology of Antimitotic Agents
por: Kirchner, Susanne, et al.
Publicado: (2022)

Molecular mechanisms underlying the antitumor activity of (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acrylamide in human colorectal cancer cells in vitro and in vivo
por: Chen, Chun-Han, et al.
Publicado: (2015)

α-Tomatine-Mediated Anti-Cancer Activity In Vitro and In Vivo through Cell Cycle- and Caspase-Independent Pathways
por: Chao, Min-Wu, et al.
Publicado: (2012)

Re-investigating PLK1 inhibitors as antimitotic agents
por: Delacour, Quentin, et al.
Publicado: (2017)

MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer
por: Huang, Han-Li, et al.
Publicado: (2016)

Microtubule S-glutathionylation as a potential approach for antimitotic agents
por: Chen, Wei, et al.
Publicado: (2012)

Effect of an antimitotic agent colchicine on thioacetamide hepatotoxicity.
por: Mangipudy, R S, et al.
Publicado: (1996)

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo
por: Chao, Min-Wu, et al.
Publicado: (2015)

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status
por: Chao, Min-Wu, et al.
Publicado: (2019)

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo
por: Huang, Han-Li, et al.
Publicado: (2014)

Proceedings: Analysis of the antimetastatic action of the antimitotic agent ICRF 159.
por: Hellmann, K., et al.
Publicado: (1974)

THE MELANOCYTE MODEL : Colchicine-like Effects of Other Antimitotic Agents
por: Malawista, Stephen E.
Publicado: (1971)

Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents
por: Olson, Oakley C., et al.
Publicado: (2017)

Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo
por: Chen, Chun-Han, et al.
Publicado: (2016)

Antimitotic drugs in the treatment of cancer
por: van Vuuren, Rustelle Janse, et al.
Publicado: (2015)

Evaluation of Antivascular and Antimitotic Effects of Tubulin Binding Agents in Solid Tumor Therapy
por: Nihei, Yukio, et al.
Publicado: (1999)

A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo
por: Wu, Yi-Wen, et al.
Publicado: (2021)

The proliferation rate paradox in antimitotic chemotherapy
por: Mitchison, Timothy J.
Publicado: (2012)

Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel
por: Fonseca, Joana, et al.
Publicado: (2016)

Equilibrative Nucleoside Transporters-1 Inhibitors Act as Anti-epileptic Agents by Inhibiting Glutamatergic Transmission
por: Ho, Shih-Yin, et al.
Publicado: (2020)

Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo
por: Huang, Han-Lin, et al.
Publicado: (2012)

Total Synthesis of the Antimitotic Marine Macrolide (−)-Leiodermatolide**
por: Paterson, Ian, et al.
Publicado: (2014)

Second-Generation Antimitotics in Cancer Clinical Trials
por: Novais, Pedro, et al.
Publicado: (2021)

Surgical treatment of neovascular glaucoma with Ex-PRESS glaucoma shunt: Case report
por: Yu, Teng-Chieh, et al.
Publicado: (2017)

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells
por: Tu, Huang-Ju, et al.
Publicado: (2018)

Correction: Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo
por: Huang, Han-Li, et al.
Publicado: (2012)

Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell line
por: Wolmarans, Elize, et al.
Publicado: (2014)

The Antimitotic Action of an Aromatic Nitrogen Mustard on Tissue Cultures
por: Rinaldini, L. M.
Publicado: (1952)

[5]-Helistatins: Tubulin-Binding Helicenes with Antimitotic Activity
por: Rushworth, James L., et al.
Publicado: (2022)

Aciculatin Induces p53-Dependent Apoptosis via MDM2 Depletion in Human Cancer Cells In Vitro and In Vivo
por: Lai, Chin-Yu, et al.
Publicado: (2012)

Candida parapsilosis keratitis treated successfully with topical and oral fluconazole
por: Li, Pei-Hsuan, et al.
Publicado: (2016)

ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory
por: Chiang, Po-Han, et al.
Publicado: (2015)

Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents
por: Gallego-Yerga, Laura, et al.
Publicado: (2023)

MT-4 Suppresses Resistant Ovarian Cancer Growth through Targeting Tubulin and HSP27
por: Pai, Hui Chen, et al.
Publicado: (2015)

Combined LTP Sublingual and Oral Immunotherapy in LTP Syndrome: Efficacy and Safety
por: Martin Iglesias, Maria Aranzazu, et al.
Publicado: (2023)

Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells
por: Chao, Min-Wu, et al.
Publicado: (2017)

Natural products as new antimitotic compounds for anticancer drug development
por: Paier, Carlos Roberto Koscky, et al.
Publicado: (2018)

Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo
por: Sailer, Alexander, et al.
Publicado: (2020)

Engineering a memory with LTD and LTP
por: Nabavi, Sadegh, et al.
Publicado: (2014)

Ocular decompression retinopathy after laser iridotomy in a patient with acute angle closure
por: Hu, Tzu-Te, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ma91712njkm852pa1ci179o61t