GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis

GPRC5A functions as a lung tumour suppressor to prevent spontaneous and environmentally induced lung carcinogenesis; however, the underlying mechanism remains unclear. Here we reveal that GPRC5A at the endoplasmic reticulum (ER) membrane suppresses synthesis of the secreted or membrane-bound protein...

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Detalles Bibliográficos
Autores principales: Wang, Jian, Farris, Alton B., Xu, Kaiming, Wang, Ping, Zhang, Xiangming, Duong, Duc M., Yi, Hong, Shu, Hui-Kuo, Sun, Shi-Yong, Wang, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899846/
https://www.ncbi.nlm.nih.gov/pubmed/27273304
http://dx.doi.org/10.1038/ncomms11795

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