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Localized mediastinal amyloidosis: A misnomer?
Amyloidosis is a disease related to abnormal protein folding and deposition of that abnormal protein between cells of the body in various tissues and organs, resulting in multiple clinical manifestations. We report a case of amyloidosis with atypical features, isolated to the mediastinum, in a 75-ye...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899862/ https://www.ncbi.nlm.nih.gov/pubmed/27326282 http://dx.doi.org/10.2484/rcr.v7i2.647 |
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author | Hoch, Michael Wang, Congli Caroline, Dina |
author_facet | Hoch, Michael Wang, Congli Caroline, Dina |
author_sort | Hoch, Michael |
collection | PubMed |
description | Amyloidosis is a disease related to abnormal protein folding and deposition of that abnormal protein between cells of the body in various tissues and organs, resulting in multiple clinical manifestations. We report a case of amyloidosis with atypical features, isolated to the mediastinum, in a 75-year-old male who presented with fatigue and shortness of breath. Amyloidosis that is isolated to the mediastinum without pulmonary parenchymal involvement is exceptionally rare. It has been hypothesized that localized mediastinal amyloidosis manifesting as amyloidomas is a distinct clinical subtype with a better prognosis than classic systemic amyloidosis. This paper describes the radiologic features of localized mediastinal amyloidosis (along with its pathologic correlation) and compares systemic and isolated disease. |
format | Online Article Text |
id | pubmed-4899862 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-48998622016-06-20 Localized mediastinal amyloidosis: A misnomer? Hoch, Michael Wang, Congli Caroline, Dina Radiol Case Rep Article Amyloidosis is a disease related to abnormal protein folding and deposition of that abnormal protein between cells of the body in various tissues and organs, resulting in multiple clinical manifestations. We report a case of amyloidosis with atypical features, isolated to the mediastinum, in a 75-year-old male who presented with fatigue and shortness of breath. Amyloidosis that is isolated to the mediastinum without pulmonary parenchymal involvement is exceptionally rare. It has been hypothesized that localized mediastinal amyloidosis manifesting as amyloidomas is a distinct clinical subtype with a better prognosis than classic systemic amyloidosis. This paper describes the radiologic features of localized mediastinal amyloidosis (along with its pathologic correlation) and compares systemic and isolated disease. Elsevier 2015-12-07 /pmc/articles/PMC4899862/ /pubmed/27326282 http://dx.doi.org/10.2484/rcr.v7i2.647 Text en © 2012 The Authors. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Hoch, Michael Wang, Congli Caroline, Dina Localized mediastinal amyloidosis: A misnomer? |
title | Localized mediastinal amyloidosis: A misnomer? |
title_full | Localized mediastinal amyloidosis: A misnomer? |
title_fullStr | Localized mediastinal amyloidosis: A misnomer? |
title_full_unstemmed | Localized mediastinal amyloidosis: A misnomer? |
title_short | Localized mediastinal amyloidosis: A misnomer? |
title_sort | localized mediastinal amyloidosis: a misnomer? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4899862/ https://www.ncbi.nlm.nih.gov/pubmed/27326282 http://dx.doi.org/10.2484/rcr.v7i2.647 |
work_keys_str_mv | AT hochmichael localizedmediastinalamyloidosisamisnomer AT wangcongli localizedmediastinalamyloidosisamisnomer AT carolinedina localizedmediastinalamyloidosisamisnomer |