Dynamic development of the pancreas from birth to adulthood

After birth the endocrine pancreas continues its development, a complex process that involves both the maturation of islet cells and a marked expansion of their numbers. New beta cells are formed both by duplication of pre-existing cells and by new differentiation (neogenesis) across the first postn...

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Detalles Bibliográficos
Autores principales: Bonner-Weir, Susan, Aguayo-Mazzucato, Cristina, Weir, Gordon C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900072/
https://www.ncbi.nlm.nih.gov/pubmed/26998806
http://dx.doi.org/10.3109/03009734.2016.1154906
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author Bonner-Weir, Susan
Aguayo-Mazzucato, Cristina
Weir, Gordon C.
author_facet Bonner-Weir, Susan
Aguayo-Mazzucato, Cristina
Weir, Gordon C.
author_sort Bonner-Weir, Susan
collection PubMed
description After birth the endocrine pancreas continues its development, a complex process that involves both the maturation of islet cells and a marked expansion of their numbers. New beta cells are formed both by duplication of pre-existing cells and by new differentiation (neogenesis) across the first postnatal weeks, with the result of beta cells of different stages of maturation even after weaning. Improving our understanding of this period of beta cell expansion could provide valuable therapeutic insights.
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spelling pubmed-49000722016-06-22 Dynamic development of the pancreas from birth to adulthood Bonner-Weir, Susan Aguayo-Mazzucato, Cristina Weir, Gordon C. Ups J Med Sci Review Articles After birth the endocrine pancreas continues its development, a complex process that involves both the maturation of islet cells and a marked expansion of their numbers. New beta cells are formed both by duplication of pre-existing cells and by new differentiation (neogenesis) across the first postnatal weeks, with the result of beta cells of different stages of maturation even after weaning. Improving our understanding of this period of beta cell expansion could provide valuable therapeutic insights. Taylor & Francis 2016-05 2016-04-02 /pmc/articles/PMC4900072/ /pubmed/26998806 http://dx.doi.org/10.3109/03009734.2016.1154906 Text en © 2016 Taylor & Francis. Published by Taylor & Francis. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
spellingShingle Review Articles
Bonner-Weir, Susan
Aguayo-Mazzucato, Cristina
Weir, Gordon C.
Dynamic development of the pancreas from birth to adulthood
title Dynamic development of the pancreas from birth to adulthood
title_full Dynamic development of the pancreas from birth to adulthood
title_fullStr Dynamic development of the pancreas from birth to adulthood
title_full_unstemmed Dynamic development of the pancreas from birth to adulthood
title_short Dynamic development of the pancreas from birth to adulthood
title_sort dynamic development of the pancreas from birth to adulthood
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900072/
https://www.ncbi.nlm.nih.gov/pubmed/26998806
http://dx.doi.org/10.3109/03009734.2016.1154906
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