Cargando…

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

Components of the unfolded protein response (UPR) modulate beta cell inflammation and death in early type 1 diabetes (T1D). The UPR is a mechanism by which cells react to the accumulation of misfolded proteins in the endoplasmic reticulum (ER). It aims to restore cellular homeostasis, but in case of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brozzi, Flora, Eizirik, Décio L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2016
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900073/ https://www.ncbi.nlm.nih.gov/pubmed/26899404 http://dx.doi.org/10.3109/03009734.2015.1135217

Ejemplares similares

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells
por: Gurzov, Esteban N., et al.
Publicado: (2008)

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
por: Colli, Maikel L., et al.
Publicado: (2020)

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic β-Cell Apoptosis in Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2012)

Checks and Balances—The Limits of β-Cell Endurance to ER Stress
por: Eizirik, Decio L., et al.
Publicado: (2017)

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2021)

In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
por: Naamane, Najib, et al.
Publicado: (2007)

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance
por: Miani, M, et al.
Publicado: (2013)

Clic4, a novel protein that sensitizes β-cells to apoptosis()
por: Patel, Dhaval, et al.
Publicado: (2015)

Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes
por: Coomans de Brachène, Alexandra, et al.
Publicado: (2022)

MCPIP1 regulates the sensitivity of pancreatic beta-cells to cytokine toxicity
por: Tyka, Karolina, et al.
Publicado: (2019)

Detailed transcriptome atlas of the pancreatic beta cell
por: Kutlu, Burak, et al.
Publicado: (2009)

Endogenous mitochondrial double‐stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells
por: Coomans de Brachène, Alexandra, et al.
Publicado: (2021)

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes
por: Marroqui, Laura, et al.
Publicado: (2015)

The Role of Beta Cell Recovery in Type 2 Diabetes Remission
por: Suleiman, Mara, et al.
Publicado: (2022)

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
por: Colli, Maikel L., et al.
Publicado: (2010)

Pancreatic beta cell ER export in health and diabetes
por: Barrabi, Cesar, et al.
Publicado: (2023)

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim
por: Nogueira, Tatiane C., et al.
Publicado: (2013)

The Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress
por: Kalwat, Michael A, et al.
Publicado: (2021)

The Transcription Factor C/EBP delta Has Anti-Apoptotic and Anti-Inflammatory Roles in Pancreatic Beta Cells
por: Moore, Fabrice, et al.
Publicado: (2012)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein Bim
por: Santin, Izortze, et al.
Publicado: (2011)

SAT068 The Golgi Transmembrane Protein GOLM1 Maintains PD-L1 Protein Levels In Islet Beta Cells In Response To Type 1 Diabetic Inflammation
por: huang, fei, et al.
Publicado: (2023)

Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways
por: Bosi, Emanuele, et al.
Publicado: (2022)

Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing
por: Demine, Stephane, et al.
Publicado: (2020)

Modulation of Autophagy Influences the Function and Survival of Human Pancreatic Beta Cells Under Endoplasmic Reticulum Stress Conditions and in Type 2 Diabetes
por: Bugliani, M., et al.
Publicado: (2019)

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
por: Moore, Fabrice, et al.
Publicado: (2009)

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
por: Demine, Stéphane, et al.
Publicado: (2020)

Nova1 is a master regulator of alternative splicing in pancreatic beta cells
por: Villate, Olatz, et al.
Publicado: (2014)

Loss of Function of WFS1 Causes ER Stress-Mediated Inflammation in Pancreatic Beta-Cells
por: Morikawa, Shuntaro, et al.
Publicado: (2022)

Tolerogenic insulin peptide therapy precipitates type 1 diabetes
por: Bergman, Marie-Louise, et al.
Publicado: (2017)

Decline and fall /
por: Waugh, Evelyn, 1903-1966
Publicado: (1937)

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance
por: Colli, Maikel L., et al.
Publicado: (2011)

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells
por: Vig, Saurabh, et al.
Publicado: (2019)

Unexpected subcellular distribution of a specific isoform of the Coxsackie and adenovirus receptor, CAR-SIV, in human pancreatic beta cells
por: Ifie, Eseoghene, et al.
Publicado: (2018)

Endoplasmic Reticulum (ER) Stress in Part Mediates Effects of Angiotensin II in Pancreatic Beta Cells
por: Ramalingam, Latha, et al.
Publicado: (2020)

Construction and validation of the APOCHIP, a spotted oligo-microarray for the study of beta-cell apoptosis
por: Magnusson, Nils E, et al.
Publicado: (2005)

β cell ER stress and the implications for immunogenicity in type 1 diabetes
por: Marré, Meghan L., et al.
Publicado: (2015)

Pancreatic beta cell autophagy is impaired in type 1 diabetes
por: Muralidharan, Charanya, et al.
Publicado: (2021)

The “Decline and Fall Off”
Publicado: (1895)

The Decline and Fall (?) of Tuberculosis.—I
por: Collis, Edgar L.
Publicado: (1922)

The Decline and Fall (?) of Tuberculosis.—II
por: Collis, Edgar L.
Publicado: (1922)

Cannot write session to /tmp/vufind_sessions/sess_o6hs6m15obe24gipi7u0of4m9p