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Allosteric Inhibition of Anti-Apoptotic MCL-1

MCL-1 is an anti-apoptotic BCL-2 family protein that has emerged as a major pathogenic factor in human cancer. Like BCL-2, MCL-1 bears a surface groove whose function is to sequester the BH3 killer domains of pro-apoptotic BCL-2 family members, a mechanism harnessed by cancer cells to establish form...

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Detalles Bibliográficos
Autores principales:	Lee, Susan, Wales, Thomas E., Escudero, Silvia, Cohen, Daniel T., Luccarelli, James, Gallagher, Catherine, Cohen, Nicole A., Huhn, Annissa J., Bird, Gregory H., Engen, John R., Walensky, Loren D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900187/ https://www.ncbi.nlm.nih.gov/pubmed/27159560 http://dx.doi.org/10.1038/nsmb.3223

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