Cargando…

Premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy

INTRODUCTION: Electroconvulsive therapy (ECT) is an effective treatment for many mental disorders, especially severe and persistent depression, bipolar disorder, and schizophrenia. The aim of this study is to compare the effect of dexmedetomidine and alfentanil on agitation, satisfaction, seizure du...

Descripción completa

Detalles Bibliográficos
Autores principales: Moshiri, Esmail, Modir, Hesameddin, Bagheri, Niknam, Mohammadbeigi, Abolfazl, Jamilian, Hamidreza, Eshrati, Babak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900344/
https://www.ncbi.nlm.nih.gov/pubmed/27052067
http://dx.doi.org/10.4103/0971-9784.179618
_version_ 1782436615731281920
author Moshiri, Esmail
Modir, Hesameddin
Bagheri, Niknam
Mohammadbeigi, Abolfazl
Jamilian, Hamidreza
Eshrati, Babak
author_facet Moshiri, Esmail
Modir, Hesameddin
Bagheri, Niknam
Mohammadbeigi, Abolfazl
Jamilian, Hamidreza
Eshrati, Babak
author_sort Moshiri, Esmail
collection PubMed
description INTRODUCTION: Electroconvulsive therapy (ECT) is an effective treatment for many mental disorders, especially severe and persistent depression, bipolar disorder, and schizophrenia. The aim of this study is to compare the effect of dexmedetomidine and alfentanil on agitation, satisfaction, seizure duration, and patients hemodynamic after ECT. MATERIALS AND METHODS: In a three phase crossover randomized clinical trial, 75 patients aged between 18 and 50 years and candidate for ECT were enrolled and assigned into three groups (25 patients in each group). All patients, respectively, took premedication of dexmedetomidine, alfentanil, or saline in three consecutive phases. Patients received 0.5 μg/kg dexmedetomidine, 10 μg/kg alfentanil or normal saline intravenously, 10 min before induction. Finally, seizure and recovery duration, satisfaction and agitation score, and hemodynamic parameters were evaluated. RESULTS: There was no significant difference about seizure duration, agitation score, and hemodynamic parameters between groups but recovery duration was significantly lower in the control group than dexmedetomidine (P = 0.016) and alfentanil group (P = 0.0001). Patients’ satisfaction was significantly higher in intervention groups (alfentanil and dexmedetomidine groups) (P = 0.0001). CONCLUSION: Given the equal effects of alfentanil and dexmedetomidine, it seems that choosing one of these two drugs for premedication of patients undergoing ECT is appropriate. Drug choice is influenced by numerous factors such as accessibility of each drug and the dominance of anesthesiologist and psychiatrist.
format Online
Article
Text
id pubmed-4900344
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-49003442016-06-16 Premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy Moshiri, Esmail Modir, Hesameddin Bagheri, Niknam Mohammadbeigi, Abolfazl Jamilian, Hamidreza Eshrati, Babak Ann Card Anaesth Original Article INTRODUCTION: Electroconvulsive therapy (ECT) is an effective treatment for many mental disorders, especially severe and persistent depression, bipolar disorder, and schizophrenia. The aim of this study is to compare the effect of dexmedetomidine and alfentanil on agitation, satisfaction, seizure duration, and patients hemodynamic after ECT. MATERIALS AND METHODS: In a three phase crossover randomized clinical trial, 75 patients aged between 18 and 50 years and candidate for ECT were enrolled and assigned into three groups (25 patients in each group). All patients, respectively, took premedication of dexmedetomidine, alfentanil, or saline in three consecutive phases. Patients received 0.5 μg/kg dexmedetomidine, 10 μg/kg alfentanil or normal saline intravenously, 10 min before induction. Finally, seizure and recovery duration, satisfaction and agitation score, and hemodynamic parameters were evaluated. RESULTS: There was no significant difference about seizure duration, agitation score, and hemodynamic parameters between groups but recovery duration was significantly lower in the control group than dexmedetomidine (P = 0.016) and alfentanil group (P = 0.0001). Patients’ satisfaction was significantly higher in intervention groups (alfentanil and dexmedetomidine groups) (P = 0.0001). CONCLUSION: Given the equal effects of alfentanil and dexmedetomidine, it seems that choosing one of these two drugs for premedication of patients undergoing ECT is appropriate. Drug choice is influenced by numerous factors such as accessibility of each drug and the dominance of anesthesiologist and psychiatrist. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4900344/ /pubmed/27052067 http://dx.doi.org/10.4103/0971-9784.179618 Text en Copyright: © 2016 Annals of Cardiac Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Moshiri, Esmail
Modir, Hesameddin
Bagheri, Niknam
Mohammadbeigi, Abolfazl
Jamilian, Hamidreza
Eshrati, Babak
Premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy
title Premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy
title_full Premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy
title_fullStr Premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy
title_full_unstemmed Premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy
title_short Premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy
title_sort premedication effect of dexmedetomidine and alfentanil on seizure time, recovery duration, and hemodynamic responses in electroconvulsive therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900344/
https://www.ncbi.nlm.nih.gov/pubmed/27052067
http://dx.doi.org/10.4103/0971-9784.179618
work_keys_str_mv AT moshiriesmail premedicationeffectofdexmedetomidineandalfentanilonseizuretimerecoverydurationandhemodynamicresponsesinelectroconvulsivetherapy
AT modirhesameddin premedicationeffectofdexmedetomidineandalfentanilonseizuretimerecoverydurationandhemodynamicresponsesinelectroconvulsivetherapy
AT bagheriniknam premedicationeffectofdexmedetomidineandalfentanilonseizuretimerecoverydurationandhemodynamicresponsesinelectroconvulsivetherapy
AT mohammadbeigiabolfazl premedicationeffectofdexmedetomidineandalfentanilonseizuretimerecoverydurationandhemodynamicresponsesinelectroconvulsivetherapy
AT jamilianhamidreza premedicationeffectofdexmedetomidineandalfentanilonseizuretimerecoverydurationandhemodynamicresponsesinelectroconvulsivetherapy
AT eshratibabak premedicationeffectofdexmedetomidineandalfentanilonseizuretimerecoverydurationandhemodynamicresponsesinelectroconvulsivetherapy