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Mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: A meta-analysis of randomized controlled trials
AIMS: Guidelines recommend mild therapeutic hypothermia (MTH) for survivors of out-of-hospital cardiac arrest (OHCA). However, there is little literature demonstrating a survival benefit. We performed a meta-analysis of randomized controlled trials (RCTs) assessing the efficacy of MTH in patients su...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900372/ https://www.ncbi.nlm.nih.gov/pubmed/26750667 http://dx.doi.org/10.4103/0971-9784.173013 |
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author | Villablanca, Pedro A. Makkiya, Mohammed Einsenberg, Evann Briceno, David F. Panagiota, Christia Menegus, Mark Garcia, Mario Sims, Daniel Ramakrishna, Harish |
author_facet | Villablanca, Pedro A. Makkiya, Mohammed Einsenberg, Evann Briceno, David F. Panagiota, Christia Menegus, Mark Garcia, Mario Sims, Daniel Ramakrishna, Harish |
author_sort | Villablanca, Pedro A. |
collection | PubMed |
description | AIMS: Guidelines recommend mild therapeutic hypothermia (MTH) for survivors of out-of-hospital cardiac arrest (OHCA). However, there is little literature demonstrating a survival benefit. We performed a meta-analysis of randomized controlled trials (RCTs) assessing the efficacy of MTH in patients successfully resuscitated from OHCA. MATERIALS AND METHODS: Electronic databases were searched for RCT involving MTH in survivors of OHCA, and the results were put through a meta-analysis. The primary endpoint was all-cause mortality, and the secondary endpoint was favorable neurological function. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using the Mantel–Haenszel method. A fixed-effect model was used and, if heterogeneity (I(2)) was >40, effects were analyzed using a random model. RESULTS: Six RCT (n = 1400 patients) were included. Overall survival was 50.7%, and favorable neurological recovery was 45.5%. Pooled data demonstrated no significant all-cause mortality (OR, 0.81; 95% CI 0.55–1.21) or neurological recovery (OR, 0.77; 95% CI 0.47–1.24). No evidence of publication bias was observed. CONCLUSION: This meta-analysis demonstrated that MTH did not confer benefit on overall survival rate and neurological recovery in patients resuscitated from OHCA. |
format | Online Article Text |
id | pubmed-4900372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-49003722016-06-16 Mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: A meta-analysis of randomized controlled trials Villablanca, Pedro A. Makkiya, Mohammed Einsenberg, Evann Briceno, David F. Panagiota, Christia Menegus, Mark Garcia, Mario Sims, Daniel Ramakrishna, Harish Ann Card Anaesth Original Article AIMS: Guidelines recommend mild therapeutic hypothermia (MTH) for survivors of out-of-hospital cardiac arrest (OHCA). However, there is little literature demonstrating a survival benefit. We performed a meta-analysis of randomized controlled trials (RCTs) assessing the efficacy of MTH in patients successfully resuscitated from OHCA. MATERIALS AND METHODS: Electronic databases were searched for RCT involving MTH in survivors of OHCA, and the results were put through a meta-analysis. The primary endpoint was all-cause mortality, and the secondary endpoint was favorable neurological function. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using the Mantel–Haenszel method. A fixed-effect model was used and, if heterogeneity (I(2)) was >40, effects were analyzed using a random model. RESULTS: Six RCT (n = 1400 patients) were included. Overall survival was 50.7%, and favorable neurological recovery was 45.5%. Pooled data demonstrated no significant all-cause mortality (OR, 0.81; 95% CI 0.55–1.21) or neurological recovery (OR, 0.77; 95% CI 0.47–1.24). No evidence of publication bias was observed. CONCLUSION: This meta-analysis demonstrated that MTH did not confer benefit on overall survival rate and neurological recovery in patients resuscitated from OHCA. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4900372/ /pubmed/26750667 http://dx.doi.org/10.4103/0971-9784.173013 Text en Copyright: © 2016 Annals of Cardiac Anaesthesia http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Villablanca, Pedro A. Makkiya, Mohammed Einsenberg, Evann Briceno, David F. Panagiota, Christia Menegus, Mark Garcia, Mario Sims, Daniel Ramakrishna, Harish Mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: A meta-analysis of randomized controlled trials |
title | Mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: A meta-analysis of randomized controlled trials |
title_full | Mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: A meta-analysis of randomized controlled trials |
title_fullStr | Mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: A meta-analysis of randomized controlled trials |
title_full_unstemmed | Mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: A meta-analysis of randomized controlled trials |
title_short | Mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: A meta-analysis of randomized controlled trials |
title_sort | mild therapeutic hypothermia in patients resuscitated from out-of-hospital cardiac arrest: a meta-analysis of randomized controlled trials |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900372/ https://www.ncbi.nlm.nih.gov/pubmed/26750667 http://dx.doi.org/10.4103/0971-9784.173013 |
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