Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Sustained glucose and glutamine transport are essential for activated T lymphocytes to support ATP and macromolecule biosynthesis. We now show that glutamine and glucose also fuel an indispensible dynamic regulation of intracellular protein O-GlcNAcylation at key stages of T cell development, transf...

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Detalles Bibliográficos
Autores principales: Swamy, Mahima, Pathak, Shalini, Grzes, Katarzyna M., Damerow, Sebastian, Sinclair, Linda V., van Aalten, Daan M. F., Cantrell, Doreen A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900450/
https://www.ncbi.nlm.nih.gov/pubmed/27111141
http://dx.doi.org/10.1038/ni.3439

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