Cargando…

Optimizing Timing of Immunotherapy Improves Control of Tumors by Hypofractionated Radiation Therapy

The anecdotal reports of promising results seen with immunotherapy and radiation in advanced malignancies have prompted several trials combining immunotherapy and radiation. However, the ideal timing of immunotherapy with radiation has not been clarified. Tumor bearing mice were treated with 20Gy ra...

Descripción completa

Detalles Bibliográficos
Autores principales:	Young, Kristina H., Baird, Jason R., Savage, Talicia, Cottam, Benjamin, Friedman, David, Bambina, Shelly, Messenheimer, David J., Fox, Bernard, Newell, Pippa, Bahjat, Keith S., Gough, Michael J., Crittenden, Marka R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900555/ https://www.ncbi.nlm.nih.gov/pubmed/27281029 http://dx.doi.org/10.1371/journal.pone.0157164

Ejemplares similares

The Peripheral Myeloid Expansion Driven by Murine Cancer Progression Is Reversed by Radiation Therapy of the Tumor
por: Crittenden, Marka R., et al.
Publicado: (2013)

Expression of NF-κB p50 in Tumor Stroma Limits the Control of Tumors by Radiation Therapy
por: Crittenden, Marka R., et al.
Publicado: (2012)

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy
por: Crittenden, Marka R., et al.
Publicado: (2016)

Preparative immunotherapy with anti-OX40 and anti-CTLA4 improves the response to chemotherapy
por: Friedman, David J, et al.
Publicado: (2014)

Immune consequences of CT-guided radiation therapy of mouse mammary tumors
por: Gough, Michael J, et al.
Publicado: (2013)

Intratumoral injection of STING ligand promotes abscopal effect
por: Baird, Jason R, et al.
Publicado: (2014)

Improved efficacy of radiation in combination with TGFβ inhibition in a colorectal cancer mouse model
por: Young, Kristina H, et al.
Publicado: (2013)

Programmed cell death-1 blockade in combination with stereotactic radiation in an orthotopic mouse model of hepatocellular carcinoma
por: Friedman, David, et al.
Publicado: (2015)

Radiation therapy and vaccination against tumor-specific EGFRvIII effectively clears tumors in a murine model of head and neck squamous cell carcinoma
por: Uhde, Lauren, et al.
Publicado: (2015)

A hypofractionated radiation regimen avoids the lymphopenia associated with neoadjuvant chemoradiation therapy of borderline resectable and locally advanced pancreatic adenocarcinoma
por: Crocenzi, Todd, et al.
Publicado: (2016)

Listeria monocytogenes-infected human monocytic derived dendritic cells activate Vγ9Vδ2 T cells independently of HMBPP production
por: Alice, Alejandro F., et al.
Publicado: (2021)

Tumor control by intravenous administration of STING ligand requires combination with precisely timed radiation therapy
por: Baird, Jason, et al.
Publicado: (2015)

Blockade of fibroblast activation protein in combination with radiation treatment in murine models of pancreatic adenocarcinoma
por: Gunderson, Andrew J., et al.
Publicado: (2019)

Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity
por: Crittenden, Marka R., et al.
Publicado: (2018)

ICOS is upregulated on T cells following radiation and agonism combined with radiation results in enhanced tumor control
por: Blair, Tiffany, et al.
Publicado: (2022)

A microbial-based cancer vaccine for induction of EGFRvIII-specific CD8+ T cells and anti-tumor immunity
por: Zebertavage, Lauren, et al.
Publicado: (2019)

A platform for locoregional T-cell immunotherapy to control HNSCC recurrence following tumor resection
por: Sharon, Shay, et al.
Publicado: (2021)

Circulating immune cells in patients with surgically resected nonfunctional pancreatic neuroendocrine tumors
por: Jutric, Zeljka, et al.
Publicado: (2015)

STING expression and response to treatment with STING ligands in premalignant and malignant disease
por: Baird, Jason R., et al.
Publicado: (2017)

Correction: STING expression and response to treatment with STING ligands in premalignant and malignant disease
por: Baird, Jason R., et al.
Publicado: (2018)

Moving beyond the T cell synapse for combination neoadjuvant immunotherapy in head and neck cancer
por: Bell, R. Bryan, et al.
Publicado: (2022)

Role of the immunosuppressive microenvironment in immunotherapy
por: Tormoen, Garth W., et al.
Publicado: (2018)

The Impact of the Myeloid Response to Radiation Therapy
por: Gough, Michael J., et al.
Publicado: (2013)

Explant Modeling of the Immune Environment of Head and Neck Cancer
por: Sharon, Shay, et al.
Publicado: (2021)

The paradox of radiation and T cells in tumors
por: Gough, Michael J., et al.
Publicado: (2022)

Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy
por: Blair, Tiffany C, et al.
Publicado: (2022)

Tumor resident memory CD8 T cells and concomitant tumor immunity develop independently of CD4 help
por: Medler, Terry R., et al.
Publicado: (2023)

Radiation and immunotherapy: Renewed allies in the war on cancer
por: Seung, Steven K., et al.
Publicado: (2012)

The TAM family as a therapeutic target in combination with radiation therapy
por: Tormoen, Garth W., et al.
Publicado: (2017)

A Self-Help Program for Memory CD8+ T Cells: Positive Feedback via CD40-CD40L Signaling as a Critical Determinant of Secondary Expansion
por: Shugart, Jessica A., et al.
Publicado: (2013)

Transcriptional Upregulation of NLRC5 by Radiation Drives STING- and Interferon-Independent MHC-I Expression on Cancer Cells and T Cell Cytotoxicity
por: Zebertavage, Lauren K., et al.
Publicado: (2020)

Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer
por: Bernard, Brady, et al.
Publicado: (2020)

Serum immunoregulatory proteins as predictors of overall survival of metastatic melanoma patients treated with ipilimumab
por: Koguchi, Yoshinobu, et al.
Publicado: (2015)

Defining Immunogenic and Radioimmunogenic Tumors
por: Medler, Terry R., et al.
Publicado: (2021)

Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model
por: McGinnis, Gwendolyn J., et al.
Publicado: (2016)

The Dynamic Entropy of Tumor Immune Infiltrates: The Impact of Recirculation, Antigen-Specific Interactions, and Retention on T Cells in Tumors
por: Blair, Tiffany C., et al.
Publicado: (2021)

Myeloid MyD88 restricts CD8(+) T cell response to radiation therapy in pancreatic cancer
por: Medler, Terry R., et al.
Publicado: (2023)

Hypofractionated Postmastectomy Radiation Therapy
por: Sayan, Mutlay, et al.
Publicado: (2020)

Implantable biomaterials to provide local immunotherapy following surgical resection
por: Gough, Michael J., et al.
Publicado: (2018)

Phase I study of safety and immunogenicity of ADU-623, a live-attenuated listeria monocytogenes vaccine (ΔactA/ΔinlB) expressing EGFRVIII and NY-ESO-1, in patients with who grade III/IV astrocytomas
por: Crittenden, Marka, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_t3bm3ii9lvap7k90ej4hqqkt1l