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Data from acellular human heart matrix

Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our exp...

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Detalles Bibliográficos
Autores principales: Sánchez, Pedro L, Fernández-Santos, Mª Eugenia, Espinosa, Mª Angeles, González-Nicolas, Mª Angeles, Acebes, Judith R, Costanza, Salvatore, Moscoso, Isabel, Rodríguez, Hugo, García, Julio, Romero, Jesús, Kren, Stefan M, Bermejo, Javier, Yotti, Raquel, del Villar, Candelas Pérez, Sanz-Ruiz, Ricardo, Elizaga, Jaime, Taylor, Doris A, Fernández-Avilés, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900585/
https://www.ncbi.nlm.nih.gov/pubmed/27331090
http://dx.doi.org/10.1016/j.dib.2016.04.069
Descripción
Sumario:Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our experience decellularizing and testing structural integrity and composition of a large series of human hearts, “Acellular human heart matrix: a critical step toward whole heat grafts” (Sanchez et al., 2015) [1]. Here we provide the information about the heart decellularization technique, the valve competence evaluation of the decellularized scaffolds, the integrity evaluation of epicardial and myocardial coronary circulation, the pressure volume measurements, the primers used to assess cardiac muscle gene expression and, the characteristics of donors, donor hearts, scaffolds and perfusion decellularization process.