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Data from acellular human heart matrix
Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our exp...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900585/ https://www.ncbi.nlm.nih.gov/pubmed/27331090 http://dx.doi.org/10.1016/j.dib.2016.04.069 |
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author | Sánchez, Pedro L Fernández-Santos, Mª Eugenia Espinosa, Mª Angeles González-Nicolas, Mª Angeles Acebes, Judith R Costanza, Salvatore Moscoso, Isabel Rodríguez, Hugo García, Julio Romero, Jesús Kren, Stefan M Bermejo, Javier Yotti, Raquel del Villar, Candelas Pérez Sanz-Ruiz, Ricardo Elizaga, Jaime Taylor, Doris A Fernández-Avilés, Francisco |
author_facet | Sánchez, Pedro L Fernández-Santos, Mª Eugenia Espinosa, Mª Angeles González-Nicolas, Mª Angeles Acebes, Judith R Costanza, Salvatore Moscoso, Isabel Rodríguez, Hugo García, Julio Romero, Jesús Kren, Stefan M Bermejo, Javier Yotti, Raquel del Villar, Candelas Pérez Sanz-Ruiz, Ricardo Elizaga, Jaime Taylor, Doris A Fernández-Avilés, Francisco |
author_sort | Sánchez, Pedro L |
collection | PubMed |
description | Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our experience decellularizing and testing structural integrity and composition of a large series of human hearts, “Acellular human heart matrix: a critical step toward whole heat grafts” (Sanchez et al., 2015) [1]. Here we provide the information about the heart decellularization technique, the valve competence evaluation of the decellularized scaffolds, the integrity evaluation of epicardial and myocardial coronary circulation, the pressure volume measurements, the primers used to assess cardiac muscle gene expression and, the characteristics of donors, donor hearts, scaffolds and perfusion decellularization process. |
format | Online Article Text |
id | pubmed-4900585 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-49005852016-06-21 Data from acellular human heart matrix Sánchez, Pedro L Fernández-Santos, Mª Eugenia Espinosa, Mª Angeles González-Nicolas, Mª Angeles Acebes, Judith R Costanza, Salvatore Moscoso, Isabel Rodríguez, Hugo García, Julio Romero, Jesús Kren, Stefan M Bermejo, Javier Yotti, Raquel del Villar, Candelas Pérez Sanz-Ruiz, Ricardo Elizaga, Jaime Taylor, Doris A Fernández-Avilés, Francisco Data Brief Medicine and Dentistry Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our experience decellularizing and testing structural integrity and composition of a large series of human hearts, “Acellular human heart matrix: a critical step toward whole heat grafts” (Sanchez et al., 2015) [1]. Here we provide the information about the heart decellularization technique, the valve competence evaluation of the decellularized scaffolds, the integrity evaluation of epicardial and myocardial coronary circulation, the pressure volume measurements, the primers used to assess cardiac muscle gene expression and, the characteristics of donors, donor hearts, scaffolds and perfusion decellularization process. Elsevier 2016-05-18 /pmc/articles/PMC4900585/ /pubmed/27331090 http://dx.doi.org/10.1016/j.dib.2016.04.069 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Medicine and Dentistry Sánchez, Pedro L Fernández-Santos, Mª Eugenia Espinosa, Mª Angeles González-Nicolas, Mª Angeles Acebes, Judith R Costanza, Salvatore Moscoso, Isabel Rodríguez, Hugo García, Julio Romero, Jesús Kren, Stefan M Bermejo, Javier Yotti, Raquel del Villar, Candelas Pérez Sanz-Ruiz, Ricardo Elizaga, Jaime Taylor, Doris A Fernández-Avilés, Francisco Data from acellular human heart matrix |
title | Data from acellular human heart matrix |
title_full | Data from acellular human heart matrix |
title_fullStr | Data from acellular human heart matrix |
title_full_unstemmed | Data from acellular human heart matrix |
title_short | Data from acellular human heart matrix |
title_sort | data from acellular human heart matrix |
topic | Medicine and Dentistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900585/ https://www.ncbi.nlm.nih.gov/pubmed/27331090 http://dx.doi.org/10.1016/j.dib.2016.04.069 |
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