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Data from acellular human heart matrix

Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our exp...

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Autores principales: Sánchez, Pedro L, Fernández-Santos, Mª Eugenia, Espinosa, Mª Angeles, González-Nicolas, Mª Angeles, Acebes, Judith R, Costanza, Salvatore, Moscoso, Isabel, Rodríguez, Hugo, García, Julio, Romero, Jesús, Kren, Stefan M, Bermejo, Javier, Yotti, Raquel, del Villar, Candelas Pérez, Sanz-Ruiz, Ricardo, Elizaga, Jaime, Taylor, Doris A, Fernández-Avilés, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900585/
https://www.ncbi.nlm.nih.gov/pubmed/27331090
http://dx.doi.org/10.1016/j.dib.2016.04.069
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author Sánchez, Pedro L
Fernández-Santos, Mª Eugenia
Espinosa, Mª Angeles
González-Nicolas, Mª Angeles
Acebes, Judith R
Costanza, Salvatore
Moscoso, Isabel
Rodríguez, Hugo
García, Julio
Romero, Jesús
Kren, Stefan M
Bermejo, Javier
Yotti, Raquel
del Villar, Candelas Pérez
Sanz-Ruiz, Ricardo
Elizaga, Jaime
Taylor, Doris A
Fernández-Avilés, Francisco
author_facet Sánchez, Pedro L
Fernández-Santos, Mª Eugenia
Espinosa, Mª Angeles
González-Nicolas, Mª Angeles
Acebes, Judith R
Costanza, Salvatore
Moscoso, Isabel
Rodríguez, Hugo
García, Julio
Romero, Jesús
Kren, Stefan M
Bermejo, Javier
Yotti, Raquel
del Villar, Candelas Pérez
Sanz-Ruiz, Ricardo
Elizaga, Jaime
Taylor, Doris A
Fernández-Avilés, Francisco
author_sort Sánchez, Pedro L
collection PubMed
description Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our experience decellularizing and testing structural integrity and composition of a large series of human hearts, “Acellular human heart matrix: a critical step toward whole heat grafts” (Sanchez et al., 2015) [1]. Here we provide the information about the heart decellularization technique, the valve competence evaluation of the decellularized scaffolds, the integrity evaluation of epicardial and myocardial coronary circulation, the pressure volume measurements, the primers used to assess cardiac muscle gene expression and, the characteristics of donors, donor hearts, scaffolds and perfusion decellularization process.
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spelling pubmed-49005852016-06-21 Data from acellular human heart matrix Sánchez, Pedro L Fernández-Santos, Mª Eugenia Espinosa, Mª Angeles González-Nicolas, Mª Angeles Acebes, Judith R Costanza, Salvatore Moscoso, Isabel Rodríguez, Hugo García, Julio Romero, Jesús Kren, Stefan M Bermejo, Javier Yotti, Raquel del Villar, Candelas Pérez Sanz-Ruiz, Ricardo Elizaga, Jaime Taylor, Doris A Fernández-Avilés, Francisco Data Brief Medicine and Dentistry Perfusion decellularization of cadaveric hearts removes cells and generates a cell-free extracellular matrix scaffold containing acellular vascular conduits, which are theoretically sufficient to perfuse and support tissue-engineered heart constructs. This article contains additional data of our experience decellularizing and testing structural integrity and composition of a large series of human hearts, “Acellular human heart matrix: a critical step toward whole heat grafts” (Sanchez et al., 2015) [1]. Here we provide the information about the heart decellularization technique, the valve competence evaluation of the decellularized scaffolds, the integrity evaluation of epicardial and myocardial coronary circulation, the pressure volume measurements, the primers used to assess cardiac muscle gene expression and, the characteristics of donors, donor hearts, scaffolds and perfusion decellularization process. Elsevier 2016-05-18 /pmc/articles/PMC4900585/ /pubmed/27331090 http://dx.doi.org/10.1016/j.dib.2016.04.069 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Medicine and Dentistry
Sánchez, Pedro L
Fernández-Santos, Mª Eugenia
Espinosa, Mª Angeles
González-Nicolas, Mª Angeles
Acebes, Judith R
Costanza, Salvatore
Moscoso, Isabel
Rodríguez, Hugo
García, Julio
Romero, Jesús
Kren, Stefan M
Bermejo, Javier
Yotti, Raquel
del Villar, Candelas Pérez
Sanz-Ruiz, Ricardo
Elizaga, Jaime
Taylor, Doris A
Fernández-Avilés, Francisco
Data from acellular human heart matrix
title Data from acellular human heart matrix
title_full Data from acellular human heart matrix
title_fullStr Data from acellular human heart matrix
title_full_unstemmed Data from acellular human heart matrix
title_short Data from acellular human heart matrix
title_sort data from acellular human heart matrix
topic Medicine and Dentistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900585/
https://www.ncbi.nlm.nih.gov/pubmed/27331090
http://dx.doi.org/10.1016/j.dib.2016.04.069
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