Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain

PCSK9 is a secreted ligand and negative post-translational regulator of low-density lipoprotein receptor (LDLR) in hepatocytes. Gain-of-function (GOF) or loss-of-function (LOF) mutations in PCSK9 are directly correlated with high or low plasma LDL-cholesterol levels, respectively. Therefore, PCSK9 i...

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Detalles Bibliográficos
Autores principales: Poirier, Steve, Hamouda, Hocine Ait, Villeneuve, Louis, Demers, Annie, Mayer, Gaétan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900664/
https://www.ncbi.nlm.nih.gov/pubmed/27280970
http://dx.doi.org/10.1371/journal.pone.0157230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900664/
https://www.ncbi.nlm.nih.gov/pubmed/27280970
http://dx.doi.org/10.1371/journal.pone.0157230

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