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Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment

Microcystin-LR (MCLR) is the most common cyanotoxin in contaminated aquatic systems. MCLR inhibits protein phosphatases 1 and 2A, leading to liver damage and tumor formation. MCLR is relatively stable owing to its cyclic structures. The combined UV/H(2)O(2) technology can degrade MCLR efficiently. T...

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Detalles Bibliográficos
Autores principales: Liu, Yafeng, Ren, Jing, Wang, Xiangrong, Fan, Zhengqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900665/
https://www.ncbi.nlm.nih.gov/pubmed/27281173
http://dx.doi.org/10.1371/journal.pone.0156236
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author Liu, Yafeng
Ren, Jing
Wang, Xiangrong
Fan, Zhengqiu
author_facet Liu, Yafeng
Ren, Jing
Wang, Xiangrong
Fan, Zhengqiu
author_sort Liu, Yafeng
collection PubMed
description Microcystin-LR (MCLR) is the most common cyanotoxin in contaminated aquatic systems. MCLR inhibits protein phosphatases 1 and 2A, leading to liver damage and tumor formation. MCLR is relatively stable owing to its cyclic structures. The combined UV/H(2)O(2) technology can degrade MCLR efficiently. The second-order rate constant of the reaction between MCLR and hydroxyl radical (·OH) is 2.79(±0.23)×10(10) M(−1) s(−1) based on the competition kinetics model using nitrobenzene as reference compound. The probable degradation pathway was analyzed through liquid chromatography mass spectrometry. Results suggested that the major destruction pathways of MCLR were initiated by ·OH attack on the benzene ring and diene of the Adda side chain. The corresponding aldehyde or ketone peptide residues were formed through further oxidation. Another minor destruction pathway involved ·OH attack on the methoxy group of the Adda side chain, followed by complete removal of the methoxy group. The combined UV/H(2)O(2) system is a promising technology for MCLR removal in contaminated aquatic systems.
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spelling pubmed-49006652016-06-24 Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment Liu, Yafeng Ren, Jing Wang, Xiangrong Fan, Zhengqiu PLoS One Research Article Microcystin-LR (MCLR) is the most common cyanotoxin in contaminated aquatic systems. MCLR inhibits protein phosphatases 1 and 2A, leading to liver damage and tumor formation. MCLR is relatively stable owing to its cyclic structures. The combined UV/H(2)O(2) technology can degrade MCLR efficiently. The second-order rate constant of the reaction between MCLR and hydroxyl radical (·OH) is 2.79(±0.23)×10(10) M(−1) s(−1) based on the competition kinetics model using nitrobenzene as reference compound. The probable degradation pathway was analyzed through liquid chromatography mass spectrometry. Results suggested that the major destruction pathways of MCLR were initiated by ·OH attack on the benzene ring and diene of the Adda side chain. The corresponding aldehyde or ketone peptide residues were formed through further oxidation. Another minor destruction pathway involved ·OH attack on the methoxy group of the Adda side chain, followed by complete removal of the methoxy group. The combined UV/H(2)O(2) system is a promising technology for MCLR removal in contaminated aquatic systems. Public Library of Science 2016-06-09 /pmc/articles/PMC4900665/ /pubmed/27281173 http://dx.doi.org/10.1371/journal.pone.0156236 Text en © 2016 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Liu, Yafeng
Ren, Jing
Wang, Xiangrong
Fan, Zhengqiu
Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment
title Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment
title_full Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment
title_fullStr Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment
title_full_unstemmed Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment
title_short Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment
title_sort mechanism and reaction pathways for microcystin-lr degradation through uv/h(2)o(2) treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900665/
https://www.ncbi.nlm.nih.gov/pubmed/27281173
http://dx.doi.org/10.1371/journal.pone.0156236
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