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Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment
Microcystin-LR (MCLR) is the most common cyanotoxin in contaminated aquatic systems. MCLR inhibits protein phosphatases 1 and 2A, leading to liver damage and tumor formation. MCLR is relatively stable owing to its cyclic structures. The combined UV/H(2)O(2) technology can degrade MCLR efficiently. T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900665/ https://www.ncbi.nlm.nih.gov/pubmed/27281173 http://dx.doi.org/10.1371/journal.pone.0156236 |
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author | Liu, Yafeng Ren, Jing Wang, Xiangrong Fan, Zhengqiu |
author_facet | Liu, Yafeng Ren, Jing Wang, Xiangrong Fan, Zhengqiu |
author_sort | Liu, Yafeng |
collection | PubMed |
description | Microcystin-LR (MCLR) is the most common cyanotoxin in contaminated aquatic systems. MCLR inhibits protein phosphatases 1 and 2A, leading to liver damage and tumor formation. MCLR is relatively stable owing to its cyclic structures. The combined UV/H(2)O(2) technology can degrade MCLR efficiently. The second-order rate constant of the reaction between MCLR and hydroxyl radical (·OH) is 2.79(±0.23)×10(10) M(−1) s(−1) based on the competition kinetics model using nitrobenzene as reference compound. The probable degradation pathway was analyzed through liquid chromatography mass spectrometry. Results suggested that the major destruction pathways of MCLR were initiated by ·OH attack on the benzene ring and diene of the Adda side chain. The corresponding aldehyde or ketone peptide residues were formed through further oxidation. Another minor destruction pathway involved ·OH attack on the methoxy group of the Adda side chain, followed by complete removal of the methoxy group. The combined UV/H(2)O(2) system is a promising technology for MCLR removal in contaminated aquatic systems. |
format | Online Article Text |
id | pubmed-4900665 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-49006652016-06-24 Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment Liu, Yafeng Ren, Jing Wang, Xiangrong Fan, Zhengqiu PLoS One Research Article Microcystin-LR (MCLR) is the most common cyanotoxin in contaminated aquatic systems. MCLR inhibits protein phosphatases 1 and 2A, leading to liver damage and tumor formation. MCLR is relatively stable owing to its cyclic structures. The combined UV/H(2)O(2) technology can degrade MCLR efficiently. The second-order rate constant of the reaction between MCLR and hydroxyl radical (·OH) is 2.79(±0.23)×10(10) M(−1) s(−1) based on the competition kinetics model using nitrobenzene as reference compound. The probable degradation pathway was analyzed through liquid chromatography mass spectrometry. Results suggested that the major destruction pathways of MCLR were initiated by ·OH attack on the benzene ring and diene of the Adda side chain. The corresponding aldehyde or ketone peptide residues were formed through further oxidation. Another minor destruction pathway involved ·OH attack on the methoxy group of the Adda side chain, followed by complete removal of the methoxy group. The combined UV/H(2)O(2) system is a promising technology for MCLR removal in contaminated aquatic systems. Public Library of Science 2016-06-09 /pmc/articles/PMC4900665/ /pubmed/27281173 http://dx.doi.org/10.1371/journal.pone.0156236 Text en © 2016 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Liu, Yafeng Ren, Jing Wang, Xiangrong Fan, Zhengqiu Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment |
title | Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment |
title_full | Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment |
title_fullStr | Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment |
title_full_unstemmed | Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment |
title_short | Mechanism and Reaction Pathways for Microcystin-LR Degradation through UV/H(2)O(2) Treatment |
title_sort | mechanism and reaction pathways for microcystin-lr degradation through uv/h(2)o(2) treatment |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900665/ https://www.ncbi.nlm.nih.gov/pubmed/27281173 http://dx.doi.org/10.1371/journal.pone.0156236 |
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