A Small Molecule Inhibitor Selectively Induces Apoptosis in Cells Transformed by High Risk Human Papilloma Viruses

A phenotypic high-throughput cell culture screen was performed to identify compounds that prevented proliferation of the human Papilloma virus type 16 (HPV-16) transformed cell line Ca Ski. A series of quinoxaline compounds exemplified by Compound 1 was identified. Testing against a panel of cell li...

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Detalles Bibliográficos
Autores principales: Sheaffer, Amy K., Lee, Min S., Qi, Huilin, Chaniewski, Susan, Zheng, Xiaofan, Farr, Glen A., Esposito, Kim, Harden, David, Lei, Ming, Schweizer, Liang, Friborg, Jacques, Agler, Michele, McPhee, Fiona, Gentles, Robert, Beno, Brett R., Chupak, Lou, Mason, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900674/
https://www.ncbi.nlm.nih.gov/pubmed/27280728
http://dx.doi.org/10.1371/journal.pone.0155909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900674/
https://www.ncbi.nlm.nih.gov/pubmed/27280728
http://dx.doi.org/10.1371/journal.pone.0155909

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