Transport mechanism of a glutamate transporter homologue Glt(Ph)

Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue Glt(Ph), an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations an...

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Autores principales: Ji, Yurui, Postis, Vincent L.G., Wang, Yingying, Bartlam, Mark, Goldman, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Biochemical Society Focused Meetings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900748/
https://www.ncbi.nlm.nih.gov/pubmed/27284058
http://dx.doi.org/10.1042/BST20160055
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author Ji, Yurui
Postis, Vincent L.G.
Wang, Yingying
Bartlam, Mark
Goldman, Adrian
author_facet Ji, Yurui
Postis, Vincent L.G.
Wang, Yingying
Bartlam, Mark
Goldman, Adrian
author_sort Ji, Yurui
collection PubMed
description Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue Glt(Ph), an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on Glt(Ph), in the hope of gaining some insights into the transport mechanism of this aspartate transporter.
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spelling pubmed-49007482016-06-23 Transport mechanism of a glutamate transporter homologue Glt(Ph) Ji, Yurui Postis, Vincent L.G. Wang, Yingying Bartlam, Mark Goldman, Adrian Biochem Soc Trans Biochemical Society Focused Meetings Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue Glt(Ph), an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on Glt(Ph), in the hope of gaining some insights into the transport mechanism of this aspartate transporter. Portland Press Ltd. 2016-06-09 2016-06-15 /pmc/articles/PMC4900748/ /pubmed/27284058 http://dx.doi.org/10.1042/BST20160055 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biochemical Society Focused Meetings
Ji, Yurui
Postis, Vincent L.G.
Wang, Yingying
Bartlam, Mark
Goldman, Adrian
Transport mechanism of a glutamate transporter homologue Glt(Ph)
title Transport mechanism of a glutamate transporter homologue Glt(Ph)
title_full Transport mechanism of a glutamate transporter homologue Glt(Ph)
title_fullStr Transport mechanism of a glutamate transporter homologue Glt(Ph)
title_full_unstemmed Transport mechanism of a glutamate transporter homologue Glt(Ph)
title_short Transport mechanism of a glutamate transporter homologue Glt(Ph)
title_sort transport mechanism of a glutamate transporter homologue glt(ph)
topic Biochemical Society Focused Meetings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900748/
https://www.ncbi.nlm.nih.gov/pubmed/27284058
http://dx.doi.org/10.1042/BST20160055
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