Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

Earlier reports showed that hyperplasia of sympathoadrenal cell precursors during embryogenesis in Nf1-deficient mice is independent of Nf1’s role in down-modulating RAS-MAPK signaling. We demonstrate in zebrafish that nf1 loss leads to aberrant activation of RAS signaling in MYCN-induced neuroblast...

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Detalles Bibliográficos
Autores principales: He, Shuning, Mansour, Marc R, Zimmerman, Mark W, Ki, Dong Hyuk, Layden, Hillary M, Akahane, Koshi, Gjini, Evisa, de Groh, Eric D, Perez-Atayde, Antonio R, Zhu, Shizhen, Epstein, Jonathan A, Look, A Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900799/
https://www.ncbi.nlm.nih.gov/pubmed/27130733
http://dx.doi.org/10.7554/eLife.14713

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