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Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients—Is This Applicable in Saudi Patients?
AIM: To compare the effect of different treatment regimens (oral hypoglycemic agents [OHGs], insulin therapy, and combination of both) on glycemic control and other cardiometabolic risk factors in type 2 diabetes mellitus (T2DM) patients in Saudi. SUBJECTS AND METHODS: Patients with T2DM, but no ser...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Libertas Academica
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900823/ https://www.ncbi.nlm.nih.gov/pubmed/27330334 http://dx.doi.org/10.4137/CMED.S38077 |
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author | AlSaggaf, Wafaa Asiri, Mohammed Ajlan, Balgees Afif, Alaa Bin Khalil, Roaa Salman, Anas Bin Alghamdi, Ahmed Bashawieh, Osama Alamoudi, Atheer Aljahdali, Abeer Aljahdali, Nouf Patwa, Hussam Bakhaidar, Mohammed Bahijri, Suhad M. Ahmed, Maimoona Al-Shali, Khalid Bokhari, Samia Alhozali, Amani Borai, Anwar Ajabnoor, Ghada Tuomilehto, Jaakko |
author_facet | AlSaggaf, Wafaa Asiri, Mohammed Ajlan, Balgees Afif, Alaa Bin Khalil, Roaa Salman, Anas Bin Alghamdi, Ahmed Bashawieh, Osama Alamoudi, Atheer Aljahdali, Abeer Aljahdali, Nouf Patwa, Hussam Bakhaidar, Mohammed Bahijri, Suhad M. Ahmed, Maimoona Al-Shali, Khalid Bokhari, Samia Alhozali, Amani Borai, Anwar Ajabnoor, Ghada Tuomilehto, Jaakko |
author_sort | AlSaggaf, Wafaa |
collection | PubMed |
description | AIM: To compare the effect of different treatment regimens (oral hypoglycemic agents [OHGs], insulin therapy, and combination of both) on glycemic control and other cardiometabolic risk factors in type 2 diabetes mellitus (T2DM) patients in Saudi. SUBJECTS AND METHODS: Patients with T2DM, but no serious diabetic complications, were randomly recruited from the diabetes clinics at two large hospitals in Jeddah, Saudi Arabia, during June 2013 to July 2014. Only those without change in treatment modality for the last 18 months were included. Blood pressure and anthropometric measurements were measured. Treatment plan was recorded from the patients’ files. Fasting blood sample was obtained to measure glucose, HbA1c, and lipid profile. RESULTS: A total of 197 patients were recruited; 41.1% were men and 58.9% were women. The mean (±SD) age was 58.5 ± 10.5 years. Most patients (60.7%) were on OHGs, 11.5% on insulin therapy, and 27.7% were using a combination of insulin and OHGs. The mean HbA1c was lower in patients using OHGs only, compared with means in those using insulin, or combined therapy in patients with disease duration of ≤10 years (P = 0.001) and also in those with a longer duration of the disease (P < 0.001). A lower mean diastolic and systolic blood pressure was found among patients on insulin alone (P < 0.01). No significant differences were found in lipid profiles among the groups. CONCLUSION: Insulin therapy, without adequate diabetes education, fails to control hyperglycemia adequately in Saudi T2DM patients. There is a challenge to find out reasons for poor control and the ways as to how to improve glycemic control in T2DM. |
format | Online Article Text |
id | pubmed-4900823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Libertas Academica |
record_format | MEDLINE/PubMed |
spelling | pubmed-49008232016-06-17 Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients—Is This Applicable in Saudi Patients? AlSaggaf, Wafaa Asiri, Mohammed Ajlan, Balgees Afif, Alaa Bin Khalil, Roaa Salman, Anas Bin Alghamdi, Ahmed Bashawieh, Osama Alamoudi, Atheer Aljahdali, Abeer Aljahdali, Nouf Patwa, Hussam Bakhaidar, Mohammed Bahijri, Suhad M. Ahmed, Maimoona Al-Shali, Khalid Bokhari, Samia Alhozali, Amani Borai, Anwar Ajabnoor, Ghada Tuomilehto, Jaakko Clin Med Insights Endocrinol Diabetes Original Research AIM: To compare the effect of different treatment regimens (oral hypoglycemic agents [OHGs], insulin therapy, and combination of both) on glycemic control and other cardiometabolic risk factors in type 2 diabetes mellitus (T2DM) patients in Saudi. SUBJECTS AND METHODS: Patients with T2DM, but no serious diabetic complications, were randomly recruited from the diabetes clinics at two large hospitals in Jeddah, Saudi Arabia, during June 2013 to July 2014. Only those without change in treatment modality for the last 18 months were included. Blood pressure and anthropometric measurements were measured. Treatment plan was recorded from the patients’ files. Fasting blood sample was obtained to measure glucose, HbA1c, and lipid profile. RESULTS: A total of 197 patients were recruited; 41.1% were men and 58.9% were women. The mean (±SD) age was 58.5 ± 10.5 years. Most patients (60.7%) were on OHGs, 11.5% on insulin therapy, and 27.7% were using a combination of insulin and OHGs. The mean HbA1c was lower in patients using OHGs only, compared with means in those using insulin, or combined therapy in patients with disease duration of ≤10 years (P = 0.001) and also in those with a longer duration of the disease (P < 0.001). A lower mean diastolic and systolic blood pressure was found among patients on insulin alone (P < 0.01). No significant differences were found in lipid profiles among the groups. CONCLUSION: Insulin therapy, without adequate diabetes education, fails to control hyperglycemia adequately in Saudi T2DM patients. There is a challenge to find out reasons for poor control and the ways as to how to improve glycemic control in T2DM. Libertas Academica 2016-06-08 /pmc/articles/PMC4900823/ /pubmed/27330334 http://dx.doi.org/10.4137/CMED.S38077 Text en © 2016 the author(s), publisher and licensee Libertas Academica Ltd. This is an open-access article distributed under the terms of the Creative Commons CC-BY-NC 3.0 license. |
spellingShingle | Original Research AlSaggaf, Wafaa Asiri, Mohammed Ajlan, Balgees Afif, Alaa Bin Khalil, Roaa Salman, Anas Bin Alghamdi, Ahmed Bashawieh, Osama Alamoudi, Atheer Aljahdali, Abeer Aljahdali, Nouf Patwa, Hussam Bakhaidar, Mohammed Bahijri, Suhad M. Ahmed, Maimoona Al-Shali, Khalid Bokhari, Samia Alhozali, Amani Borai, Anwar Ajabnoor, Ghada Tuomilehto, Jaakko Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients—Is This Applicable in Saudi Patients? |
title | Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients—Is This Applicable in Saudi Patients? |
title_full | Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients—Is This Applicable in Saudi Patients? |
title_fullStr | Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients—Is This Applicable in Saudi Patients? |
title_full_unstemmed | Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients—Is This Applicable in Saudi Patients? |
title_short | Reported Benefits of Insulin Therapy for Better Glycemic Control in Type 2 Diabetic Patients—Is This Applicable in Saudi Patients? |
title_sort | reported benefits of insulin therapy for better glycemic control in type 2 diabetic patients—is this applicable in saudi patients? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900823/ https://www.ncbi.nlm.nih.gov/pubmed/27330334 http://dx.doi.org/10.4137/CMED.S38077 |
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