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The quest for mammalian Polycomb response elements: are we there yet?
A long-standing mystery in the field of Polycomb and Trithorax regulation is how these proteins, which are highly conserved between flies and mammals, can regulate several hundred equally highly conserved target genes, but recognise these targets via cis-regulatory elements that appear to show no co...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901126/ https://www.ncbi.nlm.nih.gov/pubmed/26453572 http://dx.doi.org/10.1007/s00412-015-0539-4 |
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author | Bauer, Moritz Trupke, Johanna Ringrose, Leonie |
author_facet | Bauer, Moritz Trupke, Johanna Ringrose, Leonie |
author_sort | Bauer, Moritz |
collection | PubMed |
description | A long-standing mystery in the field of Polycomb and Trithorax regulation is how these proteins, which are highly conserved between flies and mammals, can regulate several hundred equally highly conserved target genes, but recognise these targets via cis-regulatory elements that appear to show no conservation in their DNA sequence. These elements, termed Polycomb/Trithorax response elements (PRE/TREs or PREs), are relatively well characterised in flies, but their mammalian counterparts have proved to be extremely difficult to identify. Recent progress in this endeavour has generated a wealth of data and raised several intriguing questions. Here, we ask why and to what extent mammalian PREs are so different to those of the fly. We review recent advances, evaluate current models and identify open questions in the quest for mammalian PREs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00412-015-0539-4) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4901126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-49011262016-06-27 The quest for mammalian Polycomb response elements: are we there yet? Bauer, Moritz Trupke, Johanna Ringrose, Leonie Chromosoma Review A long-standing mystery in the field of Polycomb and Trithorax regulation is how these proteins, which are highly conserved between flies and mammals, can regulate several hundred equally highly conserved target genes, but recognise these targets via cis-regulatory elements that appear to show no conservation in their DNA sequence. These elements, termed Polycomb/Trithorax response elements (PRE/TREs or PREs), are relatively well characterised in flies, but their mammalian counterparts have proved to be extremely difficult to identify. Recent progress in this endeavour has generated a wealth of data and raised several intriguing questions. Here, we ask why and to what extent mammalian PREs are so different to those of the fly. We review recent advances, evaluate current models and identify open questions in the quest for mammalian PREs. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00412-015-0539-4) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-10-09 2016 /pmc/articles/PMC4901126/ /pubmed/26453572 http://dx.doi.org/10.1007/s00412-015-0539-4 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Bauer, Moritz Trupke, Johanna Ringrose, Leonie The quest for mammalian Polycomb response elements: are we there yet? |
title | The quest for mammalian Polycomb response elements: are we there yet? |
title_full | The quest for mammalian Polycomb response elements: are we there yet? |
title_fullStr | The quest for mammalian Polycomb response elements: are we there yet? |
title_full_unstemmed | The quest for mammalian Polycomb response elements: are we there yet? |
title_short | The quest for mammalian Polycomb response elements: are we there yet? |
title_sort | quest for mammalian polycomb response elements: are we there yet? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901126/ https://www.ncbi.nlm.nih.gov/pubmed/26453572 http://dx.doi.org/10.1007/s00412-015-0539-4 |
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