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Data on the catalytic mechanism of thiol peroxidase mimics
We have recently reported SAR data describing the pharmacological activity of a series of phenyl alkyl selenides and tellurides which catalyse the oxidation of thiols by hydrogen peroxide (H(2)O(2)), “The design of redox active thiol peroxidase mimics: dihydrolipoic acid recognition correlates with...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901149/ https://www.ncbi.nlm.nih.gov/pubmed/27331089 http://dx.doi.org/10.1016/j.dib.2016.05.037 |
Sumario: | We have recently reported SAR data describing the pharmacological activity of a series of phenyl alkyl selenides and tellurides which catalyse the oxidation of thiols by hydrogen peroxide (H(2)O(2)), “The design of redox active thiol peroxidase mimics: dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action” B. Zadehvakili, S.M. McNeill, J.P. Fawcett, G.I. Giles (2016) [1]. This thiol peroxidase (TPx) activity is potentially useful for a number of therapeutic applications, as it can alter the outcome of oxidative stress related pathologies and modify redox signalling. This article presents data describing the molecular changes that occur to a TPx mimic upon exposure to H(2)O(2), and then the thiol mercaptoethanol, as characterised by UV–vis spectroscopy and HPLC retention time. |
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