Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

The inflammasome NLRP3 is activated by pathogen associated molecular patterns (PAMPs) during infection, including RNA and proteins from influenza A virus (IAV). However, chronic activation by danger associated molecular patterns (DAMPs) can be deleterious to the host. We show that blocking NLRP3 act...

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Detalles Bibliográficos
Autores principales: Tate, Michelle D., Ong, James D. H., Dowling, Jennifer K., McAuley, Julie L., Robertson, Avril B., Latz, Eicke, Drummond, Grant R., Cooper, Matthew A., Hertzog, Paul J., Mansell, Ashley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901306/
https://www.ncbi.nlm.nih.gov/pubmed/27283237
http://dx.doi.org/10.1038/srep27912

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