IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation

The single nucleotide polymorphism rs55705857, located in a non-coding but evolutionarily conserved region at 8q24.21, is strongly associated with IDH-mutant glioma development and was suggested to be a causal variant. However, the molecular mechanism underlying this association has remained unknown...

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Detalles Bibliográficos
Autores principales: Oktay, Yavuz, Ülgen, Ege, Can, Özge, Akyerli, Cemaliye B., Yüksel, Şirin, Erdemgil, Yiğit, Durası, İ. Melis, Henegariu, Octavian Ioan, Nanni, E. Paolo, Selevsek, Nathalie, Grossmann, Jonas, Erson-Omay, E. Zeynep, Bai, Hanwen, Gupta, Manu, Lee, William, Turcan, Şevin, Özpınar, Aysel, Huse, Jason T., Sav, M. Aydın, Flanagan, Adrienne, Günel, Murat, Sezerman, O. Uğur, Yakıcıer, M. Cengiz, Pamir, M. Necmettin, Özduman, Koray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901315/
https://www.ncbi.nlm.nih.gov/pubmed/27282637
http://dx.doi.org/10.1038/srep27569

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