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Curcumin inhibits HIV-1 by promoting Tat protein degradation

HIV-1 Tat is an intrinsically unfolded protein playing a pivotal role in viral replication by associating with TAR region of viral LTR. Unfolded proteins are degraded by 20S proteasome in an ubiquitin independent manner. Curcumin is known to activate 20S proteasome and promotes the degradation of in...

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Detalles Bibliográficos
Autores principales:	Ali, Amjad, Banerjea, Akhil C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901322/ https://www.ncbi.nlm.nih.gov/pubmed/27283735 http://dx.doi.org/10.1038/srep27539

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