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High-energy proton imaging for biomedical applications

The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We pr...

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Detalles Bibliográficos
Autores principales: Prall, M., Durante, M., Berger, T., Przybyla, B., Graeff, C., Lang, P. M., LaTessa, C., Shestov, L., Simoniello, P., Danly, C., Mariam, F., Merrill, F., Nedrow, P., Wilde, C., Varentsov, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901340/
https://www.ncbi.nlm.nih.gov/pubmed/27282667
http://dx.doi.org/10.1038/srep27651
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author Prall, M.
Durante, M.
Berger, T.
Przybyla, B.
Graeff, C.
Lang, P. M.
LaTessa, C.
Shestov, L.
Simoniello, P.
Danly, C.
Mariam, F.
Merrill, F.
Nedrow, P.
Wilde, C.
Varentsov, D.
author_facet Prall, M.
Durante, M.
Berger, T.
Przybyla, B.
Graeff, C.
Lang, P. M.
LaTessa, C.
Shestov, L.
Simoniello, P.
Danly, C.
Mariam, F.
Merrill, F.
Nedrow, P.
Wilde, C.
Varentsov, D.
author_sort Prall, M.
collection PubMed
description The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. Tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magneto-optics.
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spelling pubmed-49013402016-06-13 High-energy proton imaging for biomedical applications Prall, M. Durante, M. Berger, T. Przybyla, B. Graeff, C. Lang, P. M. LaTessa, C. Shestov, L. Simoniello, P. Danly, C. Mariam, F. Merrill, F. Nedrow, P. Wilde, C. Varentsov, D. Sci Rep Article The charged particle community is looking for techniques exploiting proton interactions instead of X-ray absorption for creating images of human tissue. Due to multiple Coulomb scattering inside the measured object it has shown to be highly non-trivial to achieve sufficient spatial resolution. We present imaging of biological tissue with a proton microscope. This device relies on magnetic optics, distinguishing it from most published proton imaging methods. For these methods reducing the data acquisition time to a clinically acceptable level has turned out to be challenging. In a proton microscope, data acquisition and processing are much simpler. This device even allows imaging in real time. The primary medical application will be image guidance in proton radiosurgery. Proton images demonstrating the potential for this application are presented. Tomographic reconstructions are included to raise awareness of the possibility of high-resolution proton tomography using magneto-optics. Nature Publishing Group 2016-06-10 /pmc/articles/PMC4901340/ /pubmed/27282667 http://dx.doi.org/10.1038/srep27651 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Prall, M.
Durante, M.
Berger, T.
Przybyla, B.
Graeff, C.
Lang, P. M.
LaTessa, C.
Shestov, L.
Simoniello, P.
Danly, C.
Mariam, F.
Merrill, F.
Nedrow, P.
Wilde, C.
Varentsov, D.
High-energy proton imaging for biomedical applications
title High-energy proton imaging for biomedical applications
title_full High-energy proton imaging for biomedical applications
title_fullStr High-energy proton imaging for biomedical applications
title_full_unstemmed High-energy proton imaging for biomedical applications
title_short High-energy proton imaging for biomedical applications
title_sort high-energy proton imaging for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901340/
https://www.ncbi.nlm.nih.gov/pubmed/27282667
http://dx.doi.org/10.1038/srep27651
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