The cilia-regulated proteasome and its role in the development of ciliopathies and cancer

The primary cilium is an essential structure for the mediation of numerous signaling pathways involved in the coordination and regulation of cellular processes essential for the development and maintenance of health. Consequently, ciliary dysfunction results in severe human diseases called ciliopath...

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Autores principales: Gerhardt, Christoph, Leu, Tristan, Lier, Johanna Maria, Rüther, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901515/
https://www.ncbi.nlm.nih.gov/pubmed/27293550
http://dx.doi.org/10.1186/s13630-016-0035-3
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author Gerhardt, Christoph
Leu, Tristan
Lier, Johanna Maria
Rüther, Ulrich
author_facet Gerhardt, Christoph
Leu, Tristan
Lier, Johanna Maria
Rüther, Ulrich
author_sort Gerhardt, Christoph
collection PubMed
description The primary cilium is an essential structure for the mediation of numerous signaling pathways involved in the coordination and regulation of cellular processes essential for the development and maintenance of health. Consequently, ciliary dysfunction results in severe human diseases called ciliopathies. Since many of the cilia-mediated signaling pathways are oncogenic pathways, cilia are linked to cancer. Recent studies demonstrate the existence of a cilia-regulated proteasome and that this proteasome is involved in cancer development via the progression of oncogenic, cilia-mediated signaling. This review article investigates the association between primary cilia and cancer with particular emphasis on the role of the cilia-regulated proteasome.
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spelling pubmed-49015152016-06-11 The cilia-regulated proteasome and its role in the development of ciliopathies and cancer Gerhardt, Christoph Leu, Tristan Lier, Johanna Maria Rüther, Ulrich Cilia Review The primary cilium is an essential structure for the mediation of numerous signaling pathways involved in the coordination and regulation of cellular processes essential for the development and maintenance of health. Consequently, ciliary dysfunction results in severe human diseases called ciliopathies. Since many of the cilia-mediated signaling pathways are oncogenic pathways, cilia are linked to cancer. Recent studies demonstrate the existence of a cilia-regulated proteasome and that this proteasome is involved in cancer development via the progression of oncogenic, cilia-mediated signaling. This review article investigates the association between primary cilia and cancer with particular emphasis on the role of the cilia-regulated proteasome. BioMed Central 2016-06-10 /pmc/articles/PMC4901515/ /pubmed/27293550 http://dx.doi.org/10.1186/s13630-016-0035-3 Text en © Gerhardt et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Gerhardt, Christoph
Leu, Tristan
Lier, Johanna Maria
Rüther, Ulrich
The cilia-regulated proteasome and its role in the development of ciliopathies and cancer
title The cilia-regulated proteasome and its role in the development of ciliopathies and cancer
title_full The cilia-regulated proteasome and its role in the development of ciliopathies and cancer
title_fullStr The cilia-regulated proteasome and its role in the development of ciliopathies and cancer
title_full_unstemmed The cilia-regulated proteasome and its role in the development of ciliopathies and cancer
title_short The cilia-regulated proteasome and its role in the development of ciliopathies and cancer
title_sort cilia-regulated proteasome and its role in the development of ciliopathies and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901515/
https://www.ncbi.nlm.nih.gov/pubmed/27293550
http://dx.doi.org/10.1186/s13630-016-0035-3
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