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Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder

BACKGROUND: Conversion Disorders (CD) are prevalent functional disorders. Although the pathogenesis is still not completely understood, an interaction of genetic, neurobiological, and psychosocial factors is quite likely. The aim of this study is to provide a systematic overview on imaging studies o...

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Autores principales: Boeckle, Markus, Liegl, Gregor, Jank, Robert, Pieh, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901519/
https://www.ncbi.nlm.nih.gov/pubmed/27283002
http://dx.doi.org/10.1186/s12888-016-0890-x
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author Boeckle, Markus
Liegl, Gregor
Jank, Robert
Pieh, Christoph
author_facet Boeckle, Markus
Liegl, Gregor
Jank, Robert
Pieh, Christoph
author_sort Boeckle, Markus
collection PubMed
description BACKGROUND: Conversion Disorders (CD) are prevalent functional disorders. Although the pathogenesis is still not completely understood, an interaction of genetic, neurobiological, and psychosocial factors is quite likely. The aim of this study is to provide a systematic overview on imaging studies on CDs and investigate neuronal areas involved in Motor Conversion Disorders (MCD). METHODS: A systematic literature search was conducted on CD. Subsequently a meta-analysis of functional neuroimaging studies on MCD was implemented using an Activation Likelihood Estimation (ALE). We calculated differences between patients and healthy controls as well as between affected versus unaffected sides in addition to an overall analysis in order to identify neuronal areas related to MCD. RESULTS: Patients with MCD differ from healthy controls in the amygdala, superior temporal lobe, retrosplenial area, primary motor cortex, insula, red nucleus, thalamus, anterior as well as dorsolateral prefrontal and frontal cortex. When comparing affected versus unaffected sides, temporal cortex, dorsal anterior cingulate cortex, supramarginal gyrus, dorsal temporal lobe, anterior insula, primary somatosensory cortex, superior frontal gyrus and anterior prefrontal as well as frontal cortex show significant differences. CONCLUSIONS: Neuronal areas seem to be involved in the pathogenesis, maintenance or as a result of MCD. Areas that are important for motor-planning, motor-selection or autonomic response seem to be especially relevant. Our results support the emotional unawareness theory but also underline the need of more support by conduction imaging studies on both CD and MCD.
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spelling pubmed-49015192016-06-11 Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder Boeckle, Markus Liegl, Gregor Jank, Robert Pieh, Christoph BMC Psychiatry Research Article BACKGROUND: Conversion Disorders (CD) are prevalent functional disorders. Although the pathogenesis is still not completely understood, an interaction of genetic, neurobiological, and psychosocial factors is quite likely. The aim of this study is to provide a systematic overview on imaging studies on CDs and investigate neuronal areas involved in Motor Conversion Disorders (MCD). METHODS: A systematic literature search was conducted on CD. Subsequently a meta-analysis of functional neuroimaging studies on MCD was implemented using an Activation Likelihood Estimation (ALE). We calculated differences between patients and healthy controls as well as between affected versus unaffected sides in addition to an overall analysis in order to identify neuronal areas related to MCD. RESULTS: Patients with MCD differ from healthy controls in the amygdala, superior temporal lobe, retrosplenial area, primary motor cortex, insula, red nucleus, thalamus, anterior as well as dorsolateral prefrontal and frontal cortex. When comparing affected versus unaffected sides, temporal cortex, dorsal anterior cingulate cortex, supramarginal gyrus, dorsal temporal lobe, anterior insula, primary somatosensory cortex, superior frontal gyrus and anterior prefrontal as well as frontal cortex show significant differences. CONCLUSIONS: Neuronal areas seem to be involved in the pathogenesis, maintenance or as a result of MCD. Areas that are important for motor-planning, motor-selection or autonomic response seem to be especially relevant. Our results support the emotional unawareness theory but also underline the need of more support by conduction imaging studies on both CD and MCD. BioMed Central 2016-06-10 /pmc/articles/PMC4901519/ /pubmed/27283002 http://dx.doi.org/10.1186/s12888-016-0890-x Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Boeckle, Markus
Liegl, Gregor
Jank, Robert
Pieh, Christoph
Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder
title Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder
title_full Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder
title_fullStr Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder
title_full_unstemmed Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder
title_short Neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder
title_sort neural correlates of conversion disorder: overview and meta-analysis of neuroimaging studies on motor conversion disorder
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901519/
https://www.ncbi.nlm.nih.gov/pubmed/27283002
http://dx.doi.org/10.1186/s12888-016-0890-x
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