Cargando…

Nephrotic syndrome-induced thromboembolism in adults

Nephrotic syndrome (NS) is a well-defined syndrome characterized by the presence of nephrotic range of proteinuria, hypoalbuminemia, and hyperlipidemia. Although venous thromboembolism (VTE) is a well-reported complication associated with NS, the incidence, prevalence, risk factors, treatment option...

Descripción completa

Detalles Bibliográficos
Autores principales: Al-Azzawi, Hasan F., Obi, Onyekachi C., Safi, Javeryah, Song, Mingchen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901833/
https://www.ncbi.nlm.nih.gov/pubmed/27308257
http://dx.doi.org/10.4103/2229-5151.183019
_version_ 1782436884225458176
author Al-Azzawi, Hasan F.
Obi, Onyekachi C.
Safi, Javeryah
Song, Mingchen
author_facet Al-Azzawi, Hasan F.
Obi, Onyekachi C.
Safi, Javeryah
Song, Mingchen
author_sort Al-Azzawi, Hasan F.
collection PubMed
description Nephrotic syndrome (NS) is a well-defined syndrome characterized by the presence of nephrotic range of proteinuria, hypoalbuminemia, and hyperlipidemia. Although venous thromboembolism (VTE) is a well-reported complication associated with NS, the incidence, prevalence, risk factors, treatment options, and preventative strategies are not well-established. Thromboembolic phenomena in nephrotic patients are postulated to be a result of the urinary loss of antithrombotic factors by affected kidneys and increased production of prothrombotic factors by the liver. Most cases of VTE associated with NS reported in the literature have a known diagnosis of NS. We report a case of a young female presenting with dyspnea and a pulmonary embolism. She was found to have NS and right renal vein thrombosis. We review the available literature to highlight the best approach for clinicians treating VTE in patients with NS.
format Online
Article
Text
id pubmed-4901833
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-49018332016-06-15 Nephrotic syndrome-induced thromboembolism in adults Al-Azzawi, Hasan F. Obi, Onyekachi C. Safi, Javeryah Song, Mingchen Int J Crit Illn Inj Sci Review Article Nephrotic syndrome (NS) is a well-defined syndrome characterized by the presence of nephrotic range of proteinuria, hypoalbuminemia, and hyperlipidemia. Although venous thromboembolism (VTE) is a well-reported complication associated with NS, the incidence, prevalence, risk factors, treatment options, and preventative strategies are not well-established. Thromboembolic phenomena in nephrotic patients are postulated to be a result of the urinary loss of antithrombotic factors by affected kidneys and increased production of prothrombotic factors by the liver. Most cases of VTE associated with NS reported in the literature have a known diagnosis of NS. We report a case of a young female presenting with dyspnea and a pulmonary embolism. She was found to have NS and right renal vein thrombosis. We review the available literature to highlight the best approach for clinicians treating VTE in patients with NS. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4901833/ /pubmed/27308257 http://dx.doi.org/10.4103/2229-5151.183019 Text en Copyright: © International Journal of Critical Illness and Injury Science http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution NonCommercial ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Al-Azzawi, Hasan F.
Obi, Onyekachi C.
Safi, Javeryah
Song, Mingchen
Nephrotic syndrome-induced thromboembolism in adults
title Nephrotic syndrome-induced thromboembolism in adults
title_full Nephrotic syndrome-induced thromboembolism in adults
title_fullStr Nephrotic syndrome-induced thromboembolism in adults
title_full_unstemmed Nephrotic syndrome-induced thromboembolism in adults
title_short Nephrotic syndrome-induced thromboembolism in adults
title_sort nephrotic syndrome-induced thromboembolism in adults
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901833/
https://www.ncbi.nlm.nih.gov/pubmed/27308257
http://dx.doi.org/10.4103/2229-5151.183019
work_keys_str_mv AT alazzawihasanf nephroticsyndromeinducedthromboembolisminadults
AT obionyekachic nephroticsyndromeinducedthromboembolisminadults
AT safijaveryah nephroticsyndromeinducedthromboembolisminadults
AT songmingchen nephroticsyndromeinducedthromboembolisminadults