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Opportunities and challenges for direct C–H functionalization of piperazines

Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule pharmaceuticals. Herein we summarize the current synthetic methods available to perform C–H functionalization on piperazines in order to lend structural diversity to this privileged drug scaffo...

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Detalles Bibliográficos
Autores principales:	Ye, Zhishi, Gettys, Kristen E, Dai, Mingji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901899/ https://www.ncbi.nlm.nih.gov/pubmed/27340462 http://dx.doi.org/10.3762/bjoc.12.70

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