Clinical and bioimaging results following osteochondral lesion repair using MaioRegen® allograft

AIMS AND OBJECTIVES: Surgical repair of osteochondral lesions ranging from 2 or more cm2 still is a clinical challenge. Using MaioRegen® a biocomposite allograft consisting of magnesium hydroxyapatite and equine collagen could be a promising treatment option. MATERIALS AND METHODS: 8 consecutive patients suffering from a single osteochondral lesion (2-4cm2) within the femoral condyles were prospectively enrolled. In all patients defects were filled up using MaioRegen ® via arthroscopic guided mini open arthrotomy. Clinical outcome was assessed using multiple scoring systems (IKDC/ICRS, Lysholm). Morphological as well as biochemical characteristics of the cartilage - implant surface were studied by MRI incorporating special sequences for ultra-structure research of cartilage(T2 mapping). RESULTS: Clinical scores significantly increased at 6, 12, 18 and 24 months post surgery compared to baseline. MRI morphology as well as bioimaging sequences showed variable results concerning successful integration of the implant surface into adjacent cartilage layers. CONCLUSION: One step surgical repair of osteochondral lesions using MaioRegen allografts provides encouraging short term clinical results. MRI based imaging results need further clarification by mid term studies.