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Towards the total synthesis of keramaphidin B
The enantio- and diastereoselective Michael addition of a δ-valerolactone-derived pronucleophile to a substituted furanyl nitroolefin catalysed by a bifunctional cinchonine-derived thiourea has been used as the key stereocontrolling step in a new synthetic strategy to the heavily functionalised pipe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Beilstein-Institut
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901993/ https://www.ncbi.nlm.nih.gov/pubmed/27340496 http://dx.doi.org/10.3762/bjoc.12.104 |
| _version_ | 1782436913789009920 |
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| author | Jakubec, Pavol Farley, Alistair J M Dixon, Darren J |
| author_facet | Jakubec, Pavol Farley, Alistair J M Dixon, Darren J |
| author_sort | Jakubec, Pavol |
| collection | PubMed |
| description | The enantio- and diastereoselective Michael addition of a δ-valerolactone-derived pronucleophile to a substituted furanyl nitroolefin catalysed by a bifunctional cinchonine-derived thiourea has been used as the key stereocontrolling step in a new synthetic strategy to the heavily functionalised piperidine core of keramaphidin B. |
| format | Online Article Text |
| id | pubmed-4901993 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Beilstein-Institut |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-49019932016-06-23 Towards the total synthesis of keramaphidin B Jakubec, Pavol Farley, Alistair J M Dixon, Darren J Beilstein J Org Chem Letter The enantio- and diastereoselective Michael addition of a δ-valerolactone-derived pronucleophile to a substituted furanyl nitroolefin catalysed by a bifunctional cinchonine-derived thiourea has been used as the key stereocontrolling step in a new synthetic strategy to the heavily functionalised piperidine core of keramaphidin B. Beilstein-Institut 2016-05-30 /pmc/articles/PMC4901993/ /pubmed/27340496 http://dx.doi.org/10.3762/bjoc.12.104 Text en Copyright © 2016, Jakubec et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms) |
| spellingShingle | Letter Jakubec, Pavol Farley, Alistair J M Dixon, Darren J Towards the total synthesis of keramaphidin B |
| title | Towards the total synthesis of keramaphidin B |
| title_full | Towards the total synthesis of keramaphidin B |
| title_fullStr | Towards the total synthesis of keramaphidin B |
| title_full_unstemmed | Towards the total synthesis of keramaphidin B |
| title_short | Towards the total synthesis of keramaphidin B |
| title_sort | towards the total synthesis of keramaphidin b |
| topic | Letter |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901993/ https://www.ncbi.nlm.nih.gov/pubmed/27340496 http://dx.doi.org/10.3762/bjoc.12.104 |
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