Cargando…

Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents

Muraymycins are a promising class of antimicrobial natural products. These uridine-derived nucleoside-peptide antibiotics inhibit the bacterial membrane protein translocase I (MraY), a key enzyme in the intracellular part of peptidoglycan biosynthesis. This review describes the structures of natural...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wiegmann, Daniel, Koppermann, Stefan, Wirth, Marius, Niro, Giuliana, Leyerer, Kristin, Ducho, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Beilstein-Institut 2016
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902027/ https://www.ncbi.nlm.nih.gov/pubmed/27340469 http://dx.doi.org/10.3762/bjoc.12.77

Ejemplares similares

Aminoribosylated Analogues of Muraymycin Nucleoside Antibiotics
por: Wiegmann, Daniel, et al.
Publicado: (2018)

Muraymycin Nucleoside Antibiotics: Structure-Activity Relationship for Variations in the Nucleoside Unit
por: Heib, Anna, et al.
Publicado: (2019)

Analogues of Muraymycin Nucleoside Antibiotics with Epimeric Uridine-Derived Core Structures
por: Spork, Anatol P., et al.
Publicado: (2018)

Merging Natural Products: Muraymycin–Sansanmycin Hybrid Structures as Novel Scaffolds for Potential Antibacterial Agents
por: Niro, Giuliana, et al.
Publicado: (2020)

Pyridoxal-5′-Phosphate-Dependent Alkyl Transfer in Nucleoside Antibiotic Biosynthesis
por: Cui, Zheng, et al.
Publicado: (2020)

Synthesis of an Antimicrobial Enterobactin‐Muraymycin Conjugate for Improved Activity Against Gram‐Negative Bacteria
por: Rohrbacher, Christian, et al.
Publicado: (2022)

Nucleoside Analogues as Antibacterial Agents
por: Thomson, Jessica M., et al.
Publicado: (2019)

Theoretical Study of Intermolecular Interactions between Critical Residues of Membrane Protein MraY(AA) and Promising Antibiotic Muraymycin D2
por: Malek Zadeh, Saeid, et al.
Publicado: (2020)

Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents
por: Khandazhinskaya, Anastasia L., et al.
Publicado: (2019)

Detection of RNA nucleoside modifications with the uridine-specific ribonuclease MC1 from Momordica charantia
por: Addepalli, Balasubrahmanym, et al.
Publicado: (2015)

Enzymatic synthesis of nucleoside analogues from uridines and vinyl esters in a continuous-flow microreactor
por: Du, Li-Hua, et al.
Publicado: (2018)

Identification of Mur34 as the Novel Negative Regulator Responsible for the Biosynthesis of Muraymycin in Streptomyces sp. NRRL30471
por: Xu, Dongmei, et al.
Publicado: (2013)

Application of the uridine auxotrophic host and synthetic nucleosides for a rapid selection of hydrolases from metagenomic libraries
por: Urbelienė, Nina, et al.
Publicado: (2018)

Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth
por: Matchett, Emily C., et al.
Publicado: (2022)

Palladium-catalyzed C–H olefination of uridine, deoxyuridine, uridine monophosphate and uridine analogues
por: Zhao, Qin, et al.
Publicado: (2022)

Investigation of acyclic uridine amide and 5′-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase()
por: Hampton, Shahienaz E., et al.
Publicado: (2013)

New Flexible Analogues of 8-Aza-7-deazapurine Nucleosides as Potential Antibacterial Agents
por: Khandazhinskaya, Anastasia, et al.
Publicado: (2023)

Discovery of Ligand-Efficient Scaffolds for the Design of Novel Trichomonas vaginalis Uridine Nucleoside Ribohydrolase Inhibitors Using Fragment Screening
por: Auletta, Shannon, et al.
Publicado: (2019)

Indispensable residue for uridine binding in the uridine-cytidine kinase family
por: Tomoike, Fumiaki, et al.
Publicado: (2017)

Sensitivity of Human Cancer Cells to the New Anticancer Ribo‐nucleoside TAS–106 Is Correlated with Expression of Uridine‐cytidine Kinase 2
por: Shimamoto, Yuji, et al.
Publicado: (2002)

Production of a polyclonal antibody against inosine-uridine preferring nucleoside hydrolase of Acanthamoeba castellanii and its access to diagnosis of Acanthamoeba keratitis
por: Park, So-Min, et al.
Publicado: (2020)

Synthesis of 3-fluoro-6-S-(2-S-pyridyl) nucleosides as potential lead cytostatic agents
por: Tsoukala, Evangelia, et al.
Publicado: (2010)

Effect of uridine protecting groups on the diastereoselectivity of uridine-derived aldehyde 5’-alkynylation
por: Ben Othman, Raja, et al.
Publicado: (2017)

Biosynthesis of uridine diphosphate N‐Acetylglucosamine: An underexploited pathway in the search for novel antibiotics?
por: Wyllie, Jessica A., et al.
Publicado: (2022)

Synthesis of macrocyclic nucleoside antibacterials and their interactions with MraY
por: Nakaya, Takeshi, et al.
Publicado: (2022)

Uridine Derivatives: Synthesis, Biological Evaluation, and In Silico Studies as Antimicrobial and Anticancer Agents
por: Munia, Nasrin S., et al.
Publicado: (2023)

Synthesis, spectroscopic and molecular docking studies on new schiff bases, nucleosides and α-aminophosphonate derivatives as antibacterial agents
por: Alotaibi, Saad H., et al.
Publicado: (2020)

The Demand for New Antibiotics: Antimicrobial Peptides, Nanoparticles, and Combinatorial Therapies as Future Strategies in Antibacterial Agent Design
por: León-Buitimea, Angel, et al.
Publicado: (2020)

Oxidation of 5-methylaminomethyl uridine (mnm(5)U) by Oxone Leads to Aldonitrone Derivatives
por: Zhou, Qishun, et al.
Publicado: (2018)

Protocol for UVC uridine actinometry
por: Pousty, Dana, et al.
Publicado: (2022)

Biosynthesis and Chemical Synthesis of Albomycin Nucleoside Antibiotics
por: Wang, Meiyan, et al.
Publicado: (2022)

Design, Modeling and Synthesis of 1,2,3-Triazole-Linked Nucleoside-Amino Acid Conjugates as Potential Antibacterial Agents
por: Malkowski, Sarah N., et al.
Publicado: (2017)

Nucleoside salvage and resistance to antimetabolite anticancer agents.
por: Fox, M., et al.
Publicado: (1991)

Parallel Solution-Phase Synthesis and General Biological Activity of a Uridine Antibiotic Analog Library
por: Moukha-chafiq, Omar, et al.
Publicado: (2014)

Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs
por: Mandal, Debabrata, et al.
Publicado: (2014)

Drug forecast – the peptide deformylase inhibitors as antibacterial agents
por: Guay, David R P
Publicado: (2007)

New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2
por: Maslova, A. A., et al.
Publicado: (2022)

Visualization of the Nucleolus Using Ethynyl Uridine
por: Dvořáčková, Martina, et al.
Publicado: (2018)

Hybrid Nanosystems of Antibiotics with Metal Nanoparticles—Novel Antibacterial Agents
por: Shabatina, Tatyana I., et al.
Publicado: (2023)

Chemical logic of MraY inhibition by antibacterial nucleoside natural products
por: Mashalidis, Ellene H., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_urn552be3gmi5ga5o4q25l8r3q