The synthesis of functionalized bridged polycycles via C–H bond insertion

This review presents examples from the chemical literature of syntheses of bridged-polycyclic products via C–H bond insertion by carbenes and nitrenes. Applications to natural product synthesis, a description of the essential elements in substrate-controlled reactions, and mechanistic details of tra...

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Detalles Bibliográficos
Autores principales: Shih, Jiun-Le, Chen, Po-An, May, Jeremy A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902037/
https://www.ncbi.nlm.nih.gov/pubmed/27340489
http://dx.doi.org/10.3762/bjoc.12.97
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author Shih, Jiun-Le
Chen, Po-An
May, Jeremy A
author_facet Shih, Jiun-Le
Chen, Po-An
May, Jeremy A
author_sort Shih, Jiun-Le
collection PubMed
description This review presents examples from the chemical literature of syntheses of bridged-polycyclic products via C–H bond insertion by carbenes and nitrenes. Applications to natural product synthesis, a description of the essential elements in substrate-controlled reactions, and mechanistic details of transformations are presented. Overall, these transformations allow the construction of important ring systems rapidly and efficiently, though additional catalyst development is needed.
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spelling pubmed-49020372016-06-23 The synthesis of functionalized bridged polycycles via C–H bond insertion Shih, Jiun-Le Chen, Po-An May, Jeremy A Beilstein J Org Chem Review This review presents examples from the chemical literature of syntheses of bridged-polycyclic products via C–H bond insertion by carbenes and nitrenes. Applications to natural product synthesis, a description of the essential elements in substrate-controlled reactions, and mechanistic details of transformations are presented. Overall, these transformations allow the construction of important ring systems rapidly and efficiently, though additional catalyst development is needed. Beilstein-Institut 2016-05-17 /pmc/articles/PMC4902037/ /pubmed/27340489 http://dx.doi.org/10.3762/bjoc.12.97 Text en Copyright © 2016, Shih et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Review
Shih, Jiun-Le
Chen, Po-An
May, Jeremy A
The synthesis of functionalized bridged polycycles via C–H bond insertion
title The synthesis of functionalized bridged polycycles via C–H bond insertion
title_full The synthesis of functionalized bridged polycycles via C–H bond insertion
title_fullStr The synthesis of functionalized bridged polycycles via C–H bond insertion
title_full_unstemmed The synthesis of functionalized bridged polycycles via C–H bond insertion
title_short The synthesis of functionalized bridged polycycles via C–H bond insertion
title_sort synthesis of functionalized bridged polycycles via c–h bond insertion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902037/
https://www.ncbi.nlm.nih.gov/pubmed/27340489
http://dx.doi.org/10.3762/bjoc.12.97
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