Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp(3))–H arylation

The synthesis of β-arylated alkylamides via alkyl C–H bond arylation has been realized by means of direct one-pot reactions of acyl chlorides, aryl iodides and 8-aminoquinoline. Depending on the structure of the starting materials, both single and double β-arylated alkylamides could be accessed.

Detalles Bibliográficos
Autores principales: Liu, Yunyun, Zhang, Yi, Cao, Xiaoji, Wan, Jie-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2016
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902048/
https://www.ncbi.nlm.nih.gov/pubmed/27340500
http://dx.doi.org/10.3762/bjoc.12.108
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author Liu, Yunyun
Zhang, Yi
Cao, Xiaoji
Wan, Jie-Ping
author_facet Liu, Yunyun
Zhang, Yi
Cao, Xiaoji
Wan, Jie-Ping
author_sort Liu, Yunyun
collection PubMed
description The synthesis of β-arylated alkylamides via alkyl C–H bond arylation has been realized by means of direct one-pot reactions of acyl chlorides, aryl iodides and 8-aminoquinoline. Depending on the structure of the starting materials, both single and double β-arylated alkylamides could be accessed.
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spelling pubmed-49020482016-06-23 Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp(3))–H arylation Liu, Yunyun Zhang, Yi Cao, Xiaoji Wan, Jie-Ping Beilstein J Org Chem Full Research Paper The synthesis of β-arylated alkylamides via alkyl C–H bond arylation has been realized by means of direct one-pot reactions of acyl chlorides, aryl iodides and 8-aminoquinoline. Depending on the structure of the starting materials, both single and double β-arylated alkylamides could be accessed. Beilstein-Institut 2016-06-03 /pmc/articles/PMC4902048/ /pubmed/27340500 http://dx.doi.org/10.3762/bjoc.12.108 Text en Copyright © 2016, Liu et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Liu, Yunyun
Zhang, Yi
Cao, Xiaoji
Wan, Jie-Ping
Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp(3))–H arylation
title Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp(3))–H arylation
title_full Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp(3))–H arylation
title_fullStr Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp(3))–H arylation
title_full_unstemmed Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp(3))–H arylation
title_short Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp(3))–H arylation
title_sort synthesis of β-arylated alkylamides via pd-catalyzed one-pot installation of a directing group and c(sp(3))–h arylation
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902048/
https://www.ncbi.nlm.nih.gov/pubmed/27340500
http://dx.doi.org/10.3762/bjoc.12.108
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AT caoxiaoji synthesisofbarylatedalkylamidesviapdcatalyzedonepotinstallationofadirectinggroupandcsp3harylation
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