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Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study

OBJECTIVE: To investigate the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with comitant strabismus (CS) and their relationship with behavioral performance. METHODS: Twenty patients with CS (ten men and ten women) and 20 (ten men and ten women) age-, sex-, and e...

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Autores principales: Huang, Xin, Li, Sheng-Hong, Zhou, Fu-Qing, Zhang, Ying, Zhong, Yu-Lin, Cai, Feng-Qin, Shao, Yi, Zeng, Xian-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902244/
https://www.ncbi.nlm.nih.gov/pubmed/27350747
http://dx.doi.org/10.2147/NDT.S105478
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author Huang, Xin
Li, Sheng-Hong
Zhou, Fu-Qing
Zhang, Ying
Zhong, Yu-Lin
Cai, Feng-Qin
Shao, Yi
Zeng, Xian-Jun
author_facet Huang, Xin
Li, Sheng-Hong
Zhou, Fu-Qing
Zhang, Ying
Zhong, Yu-Lin
Cai, Feng-Qin
Shao, Yi
Zeng, Xian-Jun
author_sort Huang, Xin
collection PubMed
description OBJECTIVE: To investigate the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with comitant strabismus (CS) and their relationship with behavioral performance. METHODS: Twenty patients with CS (ten men and ten women) and 20 (ten men and ten women) age-, sex-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess local features of spontaneous brain activities. Patients with CS were distinguished from HCs by receiver operating characteristic curve. Correlation analysis was performed to explore the relationship between the observed mean ReHo values of the different brain areas and behavioral performance. RESULTS: Compared to HCs, the patients with CS showed significantly increased ReHo values in the right inferior temporal cortex/fusiform gyrus/cerebellum anterior lobe, right lingual gyrus, and bilateral cingulate gyrus. We did not find any relationship between the observed mean ReHo values of the different brain areas and behavioral performance. CONCLUSION: CS causes dysfunction in many brain regions, which may explain the fusion compensation in CS.
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spelling pubmed-49022442016-06-27 Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study Huang, Xin Li, Sheng-Hong Zhou, Fu-Qing Zhang, Ying Zhong, Yu-Lin Cai, Feng-Qin Shao, Yi Zeng, Xian-Jun Neuropsychiatr Dis Treat Original Research OBJECTIVE: To investigate the underlying regional homogeneity (ReHo) of brain-activity abnormalities in patients with comitant strabismus (CS) and their relationship with behavioral performance. METHODS: Twenty patients with CS (ten men and ten women) and 20 (ten men and ten women) age-, sex-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scans. The ReHo method was used to assess local features of spontaneous brain activities. Patients with CS were distinguished from HCs by receiver operating characteristic curve. Correlation analysis was performed to explore the relationship between the observed mean ReHo values of the different brain areas and behavioral performance. RESULTS: Compared to HCs, the patients with CS showed significantly increased ReHo values in the right inferior temporal cortex/fusiform gyrus/cerebellum anterior lobe, right lingual gyrus, and bilateral cingulate gyrus. We did not find any relationship between the observed mean ReHo values of the different brain areas and behavioral performance. CONCLUSION: CS causes dysfunction in many brain regions, which may explain the fusion compensation in CS. Dove Medical Press 2016-06-03 /pmc/articles/PMC4902244/ /pubmed/27350747 http://dx.doi.org/10.2147/NDT.S105478 Text en © 2016 Huang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Huang, Xin
Li, Sheng-Hong
Zhou, Fu-Qing
Zhang, Ying
Zhong, Yu-Lin
Cai, Feng-Qin
Shao, Yi
Zeng, Xian-Jun
Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study
title Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study
title_full Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study
title_fullStr Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study
title_full_unstemmed Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study
title_short Altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional MRI study
title_sort altered intrinsic regional brain spontaneous activity in patients with comitant strabismus: a resting-state functional mri study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902244/
https://www.ncbi.nlm.nih.gov/pubmed/27350747
http://dx.doi.org/10.2147/NDT.S105478
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