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Development of a Novel Scoring System for Predicting the Risk of Colorectal Neoplasia: A Retrospective Study

OBJECTIVE: The purpose of this study was to develop a novel scoring system to screen subjects who have a high risk for colorectal neoplasia. STUDY DESIGN AND SETTING: We retrospectively analyzed 1061 subjects undergoing total colonoscopy (TCS) for the first time at Gihoku Kosei Hospital. The charact...

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Autores principales: Ohno, Tomohiko, Adachi, Seiji, Okuno, Mitsuru, Horibe, Yohei, Goto, Naoe, Iwama, Midori, Yamauchi, Osamu, Kojima, Takao, Saito, Koshiro, Ibuka, Takashi, Yasuda, Ichiro, Araki, Hiroshi, Moriwaki, Hisataka, Shimizu, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902262/
https://www.ncbi.nlm.nih.gov/pubmed/27284907
http://dx.doi.org/10.1371/journal.pone.0157269
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author Ohno, Tomohiko
Adachi, Seiji
Okuno, Mitsuru
Horibe, Yohei
Goto, Naoe
Iwama, Midori
Yamauchi, Osamu
Kojima, Takao
Saito, Koshiro
Ibuka, Takashi
Yasuda, Ichiro
Araki, Hiroshi
Moriwaki, Hisataka
Shimizu, Masahito
author_facet Ohno, Tomohiko
Adachi, Seiji
Okuno, Mitsuru
Horibe, Yohei
Goto, Naoe
Iwama, Midori
Yamauchi, Osamu
Kojima, Takao
Saito, Koshiro
Ibuka, Takashi
Yasuda, Ichiro
Araki, Hiroshi
Moriwaki, Hisataka
Shimizu, Masahito
author_sort Ohno, Tomohiko
collection PubMed
description OBJECTIVE: The purpose of this study was to develop a novel scoring system to screen subjects who have a high risk for colorectal neoplasia. STUDY DESIGN AND SETTING: We retrospectively analyzed 1061 subjects undergoing total colonoscopy (TCS) for the first time at Gihoku Kosei Hospital. The characteristics and habits of the subjects were analyzed using a multivariate logistic regression analysis. The risk score was established according to each odds ratio of the individual risk factors, and the correlations between the sum of the risk scores and the prevalence of colorectal neoplasia for each individual were evaluated. RESULTS: Age 45–59 (risk score: 2 points) and ≥60 (3 points), male gender (1 point), and habitual alcohol consumption ≥21g daily (1 point) were extracted as the significant risk factors for colorectal neoplasia. When the risk groups were determined by summing up these risk scores, the prevalence rates of colorectal neoplasia were 8.8% for the low risk group (0–2 points), 30.5% for the low-moderate risk group (3 points), 39.1% for the high-moderate risk group (4 points), and 57.6% for the high risk group (5 points). In comparison with the low risk group, the odds ratio of the low-moderate risk, the high-moderate risk, and the high risk groups were 4.6, 6.7, and 14.1 folds, respectively. CONCLUSION: Our scoring system, which linearly correlates with the prevalence rate of colorectal neoplasia, may be an effective tool for screening the subjects who have a high risk for colorectal neoplasia. These subjects, therefore, should be recommended to undergo TCS.
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spelling pubmed-49022622016-06-24 Development of a Novel Scoring System for Predicting the Risk of Colorectal Neoplasia: A Retrospective Study Ohno, Tomohiko Adachi, Seiji Okuno, Mitsuru Horibe, Yohei Goto, Naoe Iwama, Midori Yamauchi, Osamu Kojima, Takao Saito, Koshiro Ibuka, Takashi Yasuda, Ichiro Araki, Hiroshi Moriwaki, Hisataka Shimizu, Masahito PLoS One Research Article OBJECTIVE: The purpose of this study was to develop a novel scoring system to screen subjects who have a high risk for colorectal neoplasia. STUDY DESIGN AND SETTING: We retrospectively analyzed 1061 subjects undergoing total colonoscopy (TCS) for the first time at Gihoku Kosei Hospital. The characteristics and habits of the subjects were analyzed using a multivariate logistic regression analysis. The risk score was established according to each odds ratio of the individual risk factors, and the correlations between the sum of the risk scores and the prevalence of colorectal neoplasia for each individual were evaluated. RESULTS: Age 45–59 (risk score: 2 points) and ≥60 (3 points), male gender (1 point), and habitual alcohol consumption ≥21g daily (1 point) were extracted as the significant risk factors for colorectal neoplasia. When the risk groups were determined by summing up these risk scores, the prevalence rates of colorectal neoplasia were 8.8% for the low risk group (0–2 points), 30.5% for the low-moderate risk group (3 points), 39.1% for the high-moderate risk group (4 points), and 57.6% for the high risk group (5 points). In comparison with the low risk group, the odds ratio of the low-moderate risk, the high-moderate risk, and the high risk groups were 4.6, 6.7, and 14.1 folds, respectively. CONCLUSION: Our scoring system, which linearly correlates with the prevalence rate of colorectal neoplasia, may be an effective tool for screening the subjects who have a high risk for colorectal neoplasia. These subjects, therefore, should be recommended to undergo TCS. Public Library of Science 2016-06-10 /pmc/articles/PMC4902262/ /pubmed/27284907 http://dx.doi.org/10.1371/journal.pone.0157269 Text en © 2016 Ohno et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Ohno, Tomohiko
Adachi, Seiji
Okuno, Mitsuru
Horibe, Yohei
Goto, Naoe
Iwama, Midori
Yamauchi, Osamu
Kojima, Takao
Saito, Koshiro
Ibuka, Takashi
Yasuda, Ichiro
Araki, Hiroshi
Moriwaki, Hisataka
Shimizu, Masahito
Development of a Novel Scoring System for Predicting the Risk of Colorectal Neoplasia: A Retrospective Study
title Development of a Novel Scoring System for Predicting the Risk of Colorectal Neoplasia: A Retrospective Study
title_full Development of a Novel Scoring System for Predicting the Risk of Colorectal Neoplasia: A Retrospective Study
title_fullStr Development of a Novel Scoring System for Predicting the Risk of Colorectal Neoplasia: A Retrospective Study
title_full_unstemmed Development of a Novel Scoring System for Predicting the Risk of Colorectal Neoplasia: A Retrospective Study
title_short Development of a Novel Scoring System for Predicting the Risk of Colorectal Neoplasia: A Retrospective Study
title_sort development of a novel scoring system for predicting the risk of colorectal neoplasia: a retrospective study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902262/
https://www.ncbi.nlm.nih.gov/pubmed/27284907
http://dx.doi.org/10.1371/journal.pone.0157269
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