Defining the Active Fraction of Daptomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Using a Pharmacokinetic and Pharmacodynamic Approach

Our objective was to study the pharmacodynamics of daptomycin in the presence of varying concentrations of human serum (HS) in vitro to quantify the fraction of daptomycin that is ‘active’. Time kill experiments were performed with daptomycin (0 to 256 mg/L) against two MRSA strains at log-phase gro...

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Detalles Bibliográficos
Autores principales: Garonzik, Samira M., Lenhard, Justin R., Forrest, Alan, Holden, Patricia N., Bulitta, Jϋrgen B., Tsuji, Brian T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902307/
https://www.ncbi.nlm.nih.gov/pubmed/27284923
http://dx.doi.org/10.1371/journal.pone.0156131

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