Constitutive Intracellular Na(+) Excess in Purkinje Cells Promotes Arrhythmogenesis at Lower Levels of Stress Than Ventricular Myocytes From Mice With Catecholaminergic Polymorphic Ventricular Tachycardia

BACKGROUND—: In catecholaminergic polymorphic ventricular tachycardia (CPVT), cardiac Purkinje cells (PCs) appear more susceptible to Ca(2+) dysfunction than ventricular myocytes (VMs). The underlying mechanisms remain unknown. Using a CPVT mouse (RyR2(R4496C+/Cx40eGFP)), we tested whether PC intrac...

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Detalles Bibliográficos
Autores principales: Willis, B. Cicero, Pandit, Sandeep V., Ponce-Balbuena, Daniela, Zarzoso, Manuel, Guerrero-Serna, Guadalupe, Limbu, Bijay, Deo, Makarand, Camors, Emmanuel, Ramirez, Rafael J., Mironov, Sergey, Herron, Todd J., Valdivia, Héctor H., Jalife, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902321/
https://www.ncbi.nlm.nih.gov/pubmed/27169737
http://dx.doi.org/10.1161/CIRCULATIONAHA.116.021936

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